机构：[1]Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan[2]Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China[3]ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai 200031, China[4]NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China[5]Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, China[6]Department of Otolaryngology, Ningde Municipal Hospital Affiliated of Fujian Medical University (Ningde Institute of Otolaryngology), Ningde, Fujian 352100, China
The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent. Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. In this review, we specifically discuss the potential of different kinds of stem cells that hold the potential to restore sensorineural hearing loss in mammals and comprehensively explain the current therapeutic applications of stem cells in both the human and mouse inner ear to regenerate/replace the lost hair cells and spiral ganglion neurons.
基金：
Higher Education Commission (HEC) of PakistanHigher Education Commission of Pakistan
第一作者机构：[1]Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan[2]Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China
通讯作者：
通讯机构：[3]ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai 200031, China[4]NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China
推荐引用方式(GB/T 7714)：
Waqas Muhammad,Us-Salam Iram,Bibi Zainab,et al.Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals[J].NEURAL PLASTICITY.2020,2020:doi:10.1155/2020/8829660.
APA：
Waqas, Muhammad,Us-Salam, Iram,Bibi, Zainab,Wang, Yunfeng,Li, He...&He, Shuangba.(2020).Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals.NEURAL PLASTICITY,2020,
MLA：
Waqas, Muhammad,et al."Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals".NEURAL PLASTICITY 2020.(2020)
