机构：[1]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China[2]Department of Pediatrics, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China
In recent years, the obese and overweight population has increased rapidly, which has become a worldwide public health problem. However, effective medication is lacking. Our previous study identified a novel peptide, PDBSN (GLSVADLAESIMKNL), that could significantly restrict adipocyte differentiation in vitro, but its in vivo function has not been determined. Thus, in this study, we encapsulated the peptide into liposomes attached with two ligands (visceral-adipose-tissue-targeting peptide and cell-penetrating peptide) to improve stability and specificity. We then tested the peptide's function in HFD (high-fat diet)-induced obese mice and found that PDBSN could reduce weight gain and improve insulin resistance as well as lipid homeostasis. These results suggest that PDBSN may be a potential candidate for anti-obesity drug discovery. (C) 2020 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670773]; Nanjing Technological Development Program [201803012]; Jiangsu provincial key research and development program [BE2018614]; 333 high level talents training project of Jiangsu Province
第一作者机构：[1]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
共同第一作者：
通讯作者：
通讯机构：[1]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China[*1]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai, 200336, China.
推荐引用方式(GB/T 7714)：
Shen Dan,Gao Jian Fang,Xia Jia,et al.Liposome-encapsulated peptide PDBSN ameliorates high-fat-diet-induced obesity and improves metabolism homeostasis[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2020,533(1):181-187.doi:10.1016/j.bbrc.2020.09.014.
APA：
Shen, Dan,Gao, Jian Fang,Xia, Jia,Wang, Xingyun,Zhou, Yahui...&Guo, Xirong.(2020).Liposome-encapsulated peptide PDBSN ameliorates high-fat-diet-induced obesity and improves metabolism homeostasis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533,(1)
MLA：
Shen, Dan,et al."Liposome-encapsulated peptide PDBSN ameliorates high-fat-diet-induced obesity and improves metabolism homeostasis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533..1(2020):181-187
