机构：[1]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China[2]Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China[3]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China[4]Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of Kriippel-like factor 3 (KLF3). In both pancreatic cancer tissues and cell lines, the levels of miR-324-5p are significantly increased. Inhibition of miR-324-5p represses cell proliferation but promotes cell apoptosis, whereas overexpression of miR-324-5p exerts the opposite effect. Furthermore, we identified KLF3, a factor regulating pancreatic cancer cell proliferation and apoptosis, as a new direct downstream target of miR324-5p. Our results suggest that miR-324-5p plays an important role in pancreatic cancer cell proliferation and apoptosis via downregulating the expression of KLF3.
基金：
This study was partially supported by Natural Science Foundation of
China, China (31371368, 81671540); Natural Science Foundation of
Hubei Province, China (2018CFB338); Science and Technology Support
Program (Foreign Scientific and Technological Cooperation) of
Hubei Province, China (2015BHE022).
第一作者机构：[1]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China[2]Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China[3]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
通讯作者：
通讯机构：[1]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China[3]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China[*1]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.[*2]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China.
推荐引用方式(GB/T 7714)：
Wan Yiyuan,Luo Hesheng,Yang Ming,et al.miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3[J].MOLECULAR THERAPY-ONCOLYTICS.2020,18:432-442.doi:10.1016/j.omto.2020.07.011.
APA：
Wan, Yiyuan,Luo, Hesheng,Yang, Ming,Tian, Xia,Peng, Bo...&Zhang, Yadong.(2020).miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3.MOLECULAR THERAPY-ONCOLYTICS,18,
MLA：
Wan, Yiyuan,et al."miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3".MOLECULAR THERAPY-ONCOLYTICS 18.(2020):432-442
