机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Beijing 100190, P. R. China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China[3]State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, No. 20 Dongda Street, Beijing 100071, P. R. China[4]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, P. R. China
The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming. To overcome the obstacles of antibody-dependent clearance and high toxicity induced by OMVs upon intravenous injection (a classic clinically relevant delivery mode), calcium phosphate (CaP) shells are employed to cover the surface of OMVs, which enables potent OMV-based TME reprograming without side effects. Meanwhile, the pH-sensitive CaP shells facilitate the neutralization of acidic TME, leading to highly beneficial M2-to-M1 polarization of macrophages for improved antitumor effect. Moreover, the outer shells can be integrated with functional components like folic acid or photosensitizer agents, which facilitates the use of the OMV-based platform in combination therapies for a synergic therapeutic effect.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21821005]; National Key R&D Program of China [2017YFA0207900]; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB29040303]; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China) [GB/T35892-2018]
第一作者机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Beijing 100190, P. R. China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China
通讯作者：
通讯机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Beijing 100190, P. R. China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China
推荐引用方式(GB/T 7714)：
Shuang Qing,Chengliang Lyu,Li Zhu,et al.Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy[J].ADVANCED MATERIALS.2020,32(47):doi:10.1002/adma.202002085.
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