Objective To assess the prevalence of cerebral stroke in the general population of Beijing and its association with systemic risk factors and ocular diseases. Setting The population-based Beijing Eye Study was conducted in a rural and urban region of Beijing. Participants With eligibility criteria of age 50+ years and living in the study regions, 3468 subjects (78.8%) out of 4403 eligible individuals participated. Primary and secondary outcome measures The study participants underwent a detailed systemic and ophthalmological examination and an interview in which the occurrence of a previous stroke was assessed. Results A previous stroke was reported by 235 individuals (7.33%; 95% CI 6.43% to 8.24%). The prevalence of previous stroke increased from 2.0% (95% CI 0.9% to 3.1%) in the age group of 50 to <55 years to 21.9% (95% CI 16.4% to 27.4%) in the age group of 80+ years. In multivariable regression analysis, a higher prevalence of previous stroke was correlated (Nagelkerke R-2=0.20) with the systemic parameters of older age (p<0.001; OR 1.06; 95% CI 1.04 to 1.08), male gender (p<0.001; OR 0.54; 95% CI 0.40 to 0.74), lower quality of life score (p<0.001; OR 1.39; 95% CI 1.25 to 1.55), higher prevalence of arterial hypertension (p<0.001; OR 2.86; 95% CI 2.05 to 3.98), and cardiovascular disease (p<0.001; OR 1.8554; 95% CI 1.34 to 2.56), and with the ocular parameter of higher prevalence of diabetic retinopathy (p<0.001; OR 4.41; 95% CI 2.38 to 8.18) or alternatively, with higher stage of diabetic retinopathy (p<0.001; OR 1.64; 95% CI 1.26 to 2.14). Conclusions In this North Chinese population aged 50+ years, the prevalence of a previous stroke was 7.33% (95% CI 6.43% to 8.24%). After adjusting for systemic risk factors of older age, male gender and higher prevalence of arterial hypertension and cardiovascular disease, a higher prevalence of a previous stroke was significantly correlated with a higher prevalence and stage of diabetic retinopathy. The prevalence of a previous stroke increased for each step of an increase in the stage of diabetic retinopathy with an OR of 1.64 (95% CI 1.26 to 2.14), and it increased by the presence of diabetic retinopathy with an OR of 4.41 (95% CI 2.38 to 8.18).
基金：
State Natural Sciences FundNational Natural Science Foundation of China (NSFC) [81041018]; Natural Sciences Fund of Beijing government [7092021, 7112031]
第一作者机构：[1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing Tongren Hosp,Beijing Key Lab Ophthalmol &, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Ya Xing,Wei Wen Bin,Xu Liang,et al.Prevalence, risk factors and associated ocular diseases of cerebral stroke: the population-based Beijing Eye Study[J].BMJ OPEN.2020,10(9):doi:10.1136/bmjopen-2018-024646.
APA：
Wang, Ya Xing,Wei, Wen Bin,Xu, Liang&Jonas, Jost B..(2020).Prevalence, risk factors and associated ocular diseases of cerebral stroke: the population-based Beijing Eye Study.BMJ OPEN,10,(9)
MLA：
Wang, Ya Xing,et al."Prevalence, risk factors and associated ocular diseases of cerebral stroke: the population-based Beijing Eye Study".BMJ OPEN 10..9(2020)
