机构：[1]Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Department of Neurology, East Hospital, TongjiUniversity School of Medicine, Shanghai, China[3]Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[4]Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China[5]Department of Neurology, Zhongshan Hospital, FudanUniversity, Shanghai, China[6]Department of Neurology, Shanghai Punan Hospital, Shanghai, China[7]Department of Neurology, Tongji Hospital, Tongji University School ofMedicine, Shanghai, China[8]Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China[9]Department of Neurology, TongrenHospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[10]Department of Neurology, Shanghai TCM-Integrated Hospital Affiliated to Shanghai University ofTraditional Chinese Medicine, Shanghai, China[11]Department of Neurology, Shanghai Pudong New Area Hospital, Shanghai, China[12]Clinical Research Unit, Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China[13]Department of Neurology, Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai, China
Sleep disorders are common non-motor symptoms in patients with Parkinson's disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (n = 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (n = 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (beta = 4.33, CI: 3.33-5.33, P for trend <0.001), even when controlling for multiple factors. Moreover, motor complications partially mediated this relationship (indirect effect:beta = 0.355, 95% boot CI: 0.134, 0.652).Our study showed that a large proportion of PD patients suffer from multiple comorbid sleep disorders, which greatly decreases the quality of life in PD patients and is partially mediated by motor complications.
基金：
the National Key R&D Program of China (2017YFC1310300,
2016YFC1306601, 2017YFC1306002, and 2018YFC1314700), and the Shanghai Health
and Family Planning Commission Foundation (201940021).
医学