Long non-coding RNAs (lncRNAs) are under active investigation in the development of cancers, including gastric cancer (GC). Oncogenic autophagy is required for cancer cell survival. The present study aimed to investigate the regulatory role of lncRNA small nucleolar host gene 11 (SNHG11) in GC. We show that SNHG11 is upregulated in GC, and that its upregulation correlated with dismal patient outcomes. Functionally, SNHG11 aggravated oncogenic autophagy to facilitate cell proliferation, stemness, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in GC. Mechanistically, SNHG11 post-transcriptionally upregulated catenin beta 1 (CTNNB1) and autophagy related 12 (ATG12) through miR-483-3p/miR-1276, while the processing of precursor (pre-) miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3 beta ubiquitination through interacting with Cullin 4A (CUL4A) to further activate the Wnt/beta-catenin pathway. Intriguingly, SNHG11 regulated autophagy in a manner dependent on ATG12 rather than the Wnt/beta-catenin pathway, whereas SNHG11 contributed to the malignant behaviors of GC cells via both pathways. Finally, SNHG11 upregulation in GC cells was shown to be transcriptionally induced by TCF7L2. In conclusion, we reveal that SNHG11 is an oncoIncRNA in GC and might be a promising prognostic and therapeutic target for GC.
基金：
Research Fund of Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine [TRYJ201511, TRYJ201613]; Shanghai Municipal Health Commission [20194Y0373]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570549, 81472242]; Shanghai Municipal Health Bureau Key Disciplines Grant [ZK2015A24]; Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality [15411971000, 16411972700]
语种：
外文
高被引：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|1 区医学
小类|1 区生物工程与应用微生物1 区遗传学1 区医学：研究与实验
最新[2023]版：
大类|1 区医学
小类|1 区生物工程与应用微生物1 区遗传学1 区医学：研究与实验
JCR分区：
出版当年[2019]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITY
最新[2023]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITYQ1MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China
通讯作者：
通讯机构：[1]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China[*1]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.[*2]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
推荐引用方式(GB/T 7714)：
Wu Qiong,Ma Jiali,Wei Jue,et al.lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/beta-Catenin Pathway and Oncogenic Autophagy[J].MOLECULAR THERAPY.2021,29(3):1258-1278.doi:10.1016/j.ymthe.2020.10.011.
APA：
Wu, Qiong,Ma, Jiali,Wei, Jue,Meng, Wenying,Wang, Yugang&Shi, Min.(2021).lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/beta-Catenin Pathway and Oncogenic Autophagy.MOLECULAR THERAPY,29,(3)
MLA：
Wu, Qiong,et al."lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/beta-Catenin Pathway and Oncogenic Autophagy".MOLECULAR THERAPY 29..3(2021):1258-1278
医学