Ribosome biogenesis regulatory protein homolog (RRS1) is a protein required for ribosome biogenesis. Recent studies have identified an oncogenic role of RRS1 in some cancers, whereas the involvement of RRS1 in retinoblastoma (RB) remains to be determined. In this study, we aimed to explore the role of RRS1 in RB. We found that the expression of RRS1 was increased in RB tissues and cells. Lentivirus-mediated RRS1 overexpression promoted the proliferation, growth, and invasion of RB cells. Opposite results were found in RRS1 knockdown cells. In addition, RRS1 silencing induced cell cycle arrest at the G1 phase and apoptosis in RB cells, while RRS1 ectopic expression exhibited the opposite effect. At the molecular level, RRS1 activated the AKT/mTOR signaling pathway, inhibition of which largely blunted the proliferation, growth, and invasion of RB cells. Our study suggests that RRS1 functions as an oncogene in RB through activating the AKT/mTOR signaling pathway.
基金：
Priming Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital, Capital Medical University [2018-YJJ-ZZL-037]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20180208]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2018]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing, Peoples R China[2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing, Peoples R China[2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Yan Xuejing,Wu Shen,Liu Qian,et al.RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway[J].BIOMED RESEARCH INTERNATIONAL.2020,2020:doi:10.1155/2020/2420437.
APA：
Yan, Xuejing,Wu, Shen,Liu, Qian&Zhang, Jingxue.(2020).RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway.BIOMED RESEARCH INTERNATIONAL,2020,
MLA：
Yan, Xuejing,et al."RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway".BIOMED RESEARCH INTERNATIONAL 2020.(2020)
