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Masticatory Dysfunction After Computed Tomography-Guided Plasma Ablation vs. Radiofrequency Ablation on Gasserian Ganglion for Idiopathic Trigeminal Neuralgia: A Randomized Controlled Trial.

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机构： [1]Department of Pain, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. [2]Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Pain Clinic of Aesthesiology Department, Aerospace Center Hospital, Beijing, China. [4]Department of Anesthesiology, Tongren Hospital, Capital Medical University, Beijing, China. [5]Department of Anesthesiology, Aerospace Center Hospital, Beijing, China.

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关键词： Idiopathic Trigeminal Neuralgia Low-Temperature Plasma Radiofrequency Ablation Radiofrequency Thermocoagulation Masticatory Dysfunction

摘要：

We aimed to evaluate masticatory dysfunction after two different types of ablation on the Gasserian ganglion for the treatment of idiopathic trigeminal neuralgia. We hypothesized that low-temperature plasma radiofrequency ablation (LTP-RFA) was noninferior to radiofrequency thermocoagulation (RFT) with respect to initial efficacy. In the randomized, single-blind, parallel-group, noninferiority trial, 204 participants with idiopathic trigeminal neuralgia were randomly allocated to receive plasma ablation in the LTP-RFA group and radiofrequency ablation in the RFT group in a 1:1 ratio, with random block sizes of four or six. Participants were examined at baseline (T0), on the day of discharge (T1), and at the 6-month follow-up (T2). The primary end point was the clinincal effective rate in the LTP-RFA group compared with that in the RFT group after intervention on the day of discharge. Noninferiority was prespecified at -10%. The intention-to-treat analysis revealed that the initial efficacy rates were 91.2% in LTP-RFA group and 93.1% in RFT group (rate ratio [RR] = 0.979, 95% confidence interval [CI]: 0.904-1.061, P = 0.795). The difference between the two groups was 1.9% (95% CI: -5.6% to 9.4%), which showed that LTP-RFA demonstrated noninferiority compared with RFT in initial efficacy. Compared with the RFT group, the LTP-RFA group exhibited a significantly greater improvement in the maximum voltage of the masseter muscles with mean differences of 11.40 (95% CI: 10.52 to 12.27, P < 0.001) at T1 and 17.41 (95% CI: 14.68 to 20.13, P < 0.001) at T2, respectively. Similar results were observed for the asymmetry index of occlusion, the maximum voltage of the anterior temporalis, and the activity index of anterior temporalis / masseter muscles. No serious adverse events were observed in either group. Compared with the RFT group, noninferior efficacy for pain relief and improvement of masticatory function was revealed in the LTP-RFA group. © The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区麻醉学 3 区医学：内科

最新[2025]版：

大类 | 3 区医学

小类 | 3 区医学：内科 4 区麻醉学

JCR分区：

出版当年[2019]版：

Q2 ANESTHESIOLOGY Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 ANESTHESIOLOGY Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 2.9 最新[2023版] 3.2 最新五年平均 2.513 出版当年[2019版] 3.101 出版当年五年平均 2.764 出版前一年[2018版] 3.75 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Pain, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. [2]Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Pain Clinic of Aesthesiology Department, Aerospace Center Hospital, Beijing, China.

通讯机构： [*1]Department of Pain Management, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China

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Masticatory Dysfunction After Computed Tomography-Guided Plasma Ablation vs. Radiofrequency Ablation on Gasserian Ganglion for Idiopathic Trigeminal Neuralgia: A Randomized Controlled Trial.

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