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The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19

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机构: [1]Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China [2]School of Basic Medical Science, Wuhan University, Wuhan, China [3]Institute of Model Animal, Wuhan University, Wuhan, China [4]Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China [5]The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China [6]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China [7]Department of Neurology, The First People’s Hospital of Jingmen affiliated to Hubei Minzu University, Jingmen 448000, China [8]Department of General Surgery, Ezhou Central Hospital, Ezhou 436000, China [9]Department of General Surgery, Huanggang Central Hospital, Huanggang 438000, China [10]Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China [11]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Changjiang University, Jingzhou, China [12]Department of Hepatobiliary and Pancreatic Surgery, Xianning Central Hospital, Hubei Province, Xianning, China [13]Department of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou, China [14]Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China [15]Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [16]Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [17]Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China [18]Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China [19]Centre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London, UK [20]Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA [21]Departments of Anesthesiology, Physiology, and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine,University of California, Los Angeles, Los Angeles, CA, USA
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关键词: corticosteroids COVID-19 inflammatory status mortality neutrophil-to-lymphocyte ratio

摘要:
While corticosteroid therapy is effective in the treatment of patients with severe COVID-19, a quantitative clinical parameter to identify such severity and which patients would respond well to corticosteroids has not been developed. Here, Cai et al. find that a simple blood test that measures the neutrophil-to-leukocyte ratio at admission discriminates high versus low mortality risk and a better response to corticosteroid therapy. © 2021 Elsevier Inc.

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出版当年[2020]版:
大类 | 1 区 生物
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
最新[2025]版:
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
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出版当年[2019]版:
Q1 ENDOCRINOLOGY & METABOLISM Q1 CELL BIOLOGY
最新[2023]版:
Q1 CELL BIOLOGY Q1 ENDOCRINOLOGY & METABOLISM

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China [3]Institute of Model Animal, Wuhan University, Wuhan, China [4]Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China
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通讯机构: [1]Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China [2]School of Basic Medical Science, Wuhan University, Wuhan, China [3]Institute of Model Animal, Wuhan University, Wuhan, China [6]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China [14]Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China
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