机构：[1]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China[2]Department of Rehabilitation, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[3]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China[4]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China
Multiple Myeloma (MM) is a neoplastic disorder derived from the malignant proliferation of monoclonal plasma cells. It is characterized by the overproduction of immunoglobulins (Ig). We report a rare case in which bulbar palsy was the initial manifestation of IgG-MM. A 66-year-old woman initially presented with progressive dysphagia and dysarthria for half a year. Physical examination demonstrated a deviation of the uvula, difficulty in protruding tongue, and bilateral tongue atrophy. Laboratory assessments revealed anemia and prominent monoclonal elevation of IgG levels both in serum and cerebrospinal fluid (CSF). The diagnosis of IgG-MM was confirmed by the identification of plasmacytosis in bone marrow aspiration and biopsy and elevation of gamma-M protein in serum protein electrophoresis (SPEP). Therefore, the patient began to receive the chemotherapy with PAD (bortezomib-doxorubicin-dexamethasone) regimen. Her condition had been under control. MM as a hematological malignancy can affect cranial nerves and present as chronic progressive bulbar palsy.
第一作者机构：[1]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China[*1]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, No.299 Qingyang Road, Wuxi, Jiangsu 214023, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China[*1]Department of Neurology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, No.299 Qingyang Road, Wuxi, Jiangsu 214023, China.
推荐引用方式(GB/T 7714)：
Shujuan Li,Fang Gao,Weiguo Cheng,et al.Bulbar Palsy as the Initial Manifestation of Multiple Myeloma: A Case Report[J].JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION.2021,113(3):255-259.doi:10.1016/j.jnma.2020.12.007.
APA：
Shujuan Li,Fang Gao,Weiguo Cheng&Sunwei Wang.(2021).Bulbar Palsy as the Initial Manifestation of Multiple Myeloma: A Case Report.JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION,113,(3)
MLA：
Shujuan Li,et al."Bulbar Palsy as the Initial Manifestation of Multiple Myeloma: A Case Report".JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION 113..3(2021):255-259
