机构：[1]NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China[2]Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China[3]Chinese Acad Med Sci CAMS, Inst Lab Anim Sci, Beijing, Peoples R China[4]Peking Union Med Coll PUMC, Comparat Med Ctr, Beijing, Peoples R China[5]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long-term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).
基金：
National Science and Technology Major Project [2017ZX10304402]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
无
最新[2025]版：
大类|2 区医学
小类|2 区生化与分子生物学2 区医学：研究与实验
JCR分区：
出版当年[2019]版：
无
最新[2023]版：
Q2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China[2]Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China[3]Chinese Acad Med Sci CAMS, Inst Lab Anim Sci, Beijing, Peoples R China[4]Peking Union Med Coll PUMC, Comparat Med Ctr, Beijing, Peoples R China
通讯作者：
通讯机构：[1]NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China[2]Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China[3]Chinese Acad Med Sci CAMS, Inst Lab Anim Sci, Beijing, Peoples R China[4]Peking Union Med Coll PUMC, Comparat Med Ctr, Beijing, Peoples R China[*1]NHC Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
推荐引用方式(GB/T 7714)：
Li Weisha,Li Mengyuan,Yang Xingjiu,et al.Summary of animal models of myelodysplastic syndrome[J].ANIMAL MODELS AND EXPERIMENTAL MEDICINE.2021,4(1):71-76.doi:10.1002/ame2.12144.
APA：
Li, Weisha,Li, Mengyuan,Yang, Xingjiu,Zhang, Wenlong,Cao, Lin&Gao, Ran.(2021).Summary of animal models of myelodysplastic syndrome.ANIMAL MODELS AND EXPERIMENTAL MEDICINE,4,(1)
MLA：
Li, Weisha,et al."Summary of animal models of myelodysplastic syndrome".ANIMAL MODELS AND EXPERIMENTAL MEDICINE 4..1(2021):71-76
