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Advisability of primary intraocular lens implantation for infants under 2: A systematic review and meta-analysis

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机构: [1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci,Beijing T, Beijing, Peoples R China
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Purposes The present meta-analysis compared the postoperative visual performance of primary intraocular lens (IOL) implantation and primary aphakia in cataract infants. Methods PubMed, Embase, Science Direct and Cochrane Library were searched, and postoperative visual acuity (VA) and complications were extracted and pooled. Results Three randomised controlled trails (RCTs) and five retrospective studies were included. The postoperative VA of children younger than 4.5 years in primary IOL group was better than that in primary aphakia group [MD = -0.14, 95% CI: (-0.23, -0.06), P = .90]. The subgroup analysis based on RCTs and on unilateral cataract surgery revealed the same result. There was no significant difference in the incidence of glaucoma, strabismus, retinal detachment and nystagmus between primary IOL group and primary aphakia group [OR = 1.02, 95% CI: (0.62, 1.68), P = .48 for glaucoma; OR = 0.76, 95% CI: (0.30, 1.90), P = .05 for strabismus; OR = 0.49, 95% CI: (0.07, 3.30), P = .34 for retinal detachment; OR = 1.26, 95% CI: (0.68, 2.36), P = .92 for nystagmus]. The proportion of patients requiring postoperative visual axis opacification (VAO) clearing was higher in primary IOL group than that in primary aphakia group [OR = 9.22, 95% CI: (4.74, 17.96), P = .16]. Conclusion For infants under 2 years of age, primary IOL implantation would provide more visual benefits compared with primary aphakia did, though the benefits would taper off with the age reaching 4.5 years. Moreover, the current study revealed a higher VAO incidence r in primary IOL implantation group.

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出版当年[2020]版:
大类 | 4 区 医学
小类 | 3 区 医学:内科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2019]版:
Q2 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q2 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci,Beijing T, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci,Beijing T, Beijing, Peoples R China [*1]Hougou Lane 17,Chongnei St, Beijing 100005, Peoples R China
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