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Modeling human retinoblastoma using embryonic stem cell-derived retinal organoids.

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机构： [1]Laboratory of Stem Cell & Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. [2]Institute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. [3]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China. [4]Institute of Stem Cell Research, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

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Retinoblastoma (Rb) is the most prevalent intraocular malignancy in early childhood. Traditional models are unable to accurately recapitulate the origin and development of human Rb. Here, we present a protocol to establish a novel human Rb organoid (hRBO) model derived from genetically engineered human embryonic stem cells (hESCs). This hRBO model exhibits properties highly consistent with human primary Rb and can be used effectively for dissecting the origination and pathogenesis of Rb as well as for screening of potential therapies. For complete details on the use and execution of this protocol, please refer to Liu et al. (2020).© 2021 The Author(s).

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最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化研究方法

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最新[2023]版：

Q4 BIOCHEMICAL RESEARCH METHODS

影响因子： 1.3 最新[2023版] 1.5 最新五年平均 0 出版当年[2019版] 0 出版当年五年平均 0 出版前一年[2018版]

第一作者：

第一作者机构： [1]Laboratory of Stem Cell & Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. [2]Institute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

通讯作者：

通讯机构： [3]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China. [4]Institute of Stem Cell Research, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

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