详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Contemporary Update of Retinoblastoma in China: Three-Decade Changes in Epidemiology, Clinical Features, Treatments, and Outcomes

3| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTongUniversity School of Medicine, Shanghai, China [2]Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai,China [3]Department of Ophthalmology,Beijing Tongren Hospital [4]Department of Ophthalmology, The General Hospital of Chinese People's ArmedPolice Forces [5]Department of Ophthalmology, Beijing Children’s Hospital, Capital MedicalUniversity [6]Department of Ophthalmology, Quanzhou Women’s and Children’s Hospital [7]Department of Ophthalmology, Xinhua Hospital affiliated with Shanghai JiaotongUniversity School of Medicine [8]Department of Ophthalmology, Guangzhou Women and Children’s Medical Center [9]Department of Ophthalmology, Henan Children’s Hospital [10]Department of Ophthalmology, Peking University People’s Hospital [11]Department of Ophthalmology, Central South University Xiangya School ofMedicine [12]Department of Ophthalmology, Qilu Children's Hospital of Shandong University [13]Department of Ophthalmology, the First hospital Affiliated with AMU [14]Department of Ophthalmology, Shandong Provincial Hospital [15]Department of Ophthalmology, Kunming Children’s Hospital [16]Department of Ophthalmology, Wuhan University Renmin Hospital [17]Department of Ophthalmology, Hebei Children’s Hospital [18]Department of Ophthalmology, Xi'an Tangdu Hospital of No [4]Military MedicalUniversity [19]Zhongshan Ophthalmic Center, Sun Yat-sen University [20]Department of Ophthalmology, Harbin Children’s Hospital [21]Ophthalmology of the First Affiliated Hospital Anhui Medical University [22]Department of Ophthalmology, the Second affiliated Hospital of Anhui MedicalUniversity [23]Department of Ophthalmology, the Provincial Hospital Affiliated to Anhui MedicalUniversity [24]Department of Ophthalmology, the First Affiliated Hospital of Bengbu MedicalCollege [25]Department of Ophthalmogy, Yijishan Hospital, Wannan Medical College [26]Department of Ophthalmology, the Second Affiliated Hospital Zhejiang UniversitySchool of Medicine [27]Jiangsu Province Hospital [28]Children’s Hospital of Nanjing Medical University [29]Second Provincial People’s Hospital of Gansu [30]Department of Ophthalmology, Tongji Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology [31]Department of Ophthalmology, Union Hospital Affiliated with Tongji MedicalCollege, Huazhong University of Science and Technology, Wuhan [32]Department of Ophthalmology, the Second Hospital of Dalian Medical University [33]Department of Ocular Trauma and Orbital Diseases, Affiliated Eye Hospital ofNanchang University [34]The First Affiliated Hospital of Harbin Medical University, Harbin 150001,Heilongjiang Province, China [35]The Second Hospital of Jilin University [36]The Affiliated Hospital of Inner Mongolia Medical University [37]West China Hospital, Sichuan University [38]Shenzhen Eye Hospital, Shenzhen University School of Medicine [39]People's Hospital of Guangxi Zhuang Autonomous Region [40]Tibet Autonomous Region Eye Center [41]Beijing Road Clinical Department of Xinjiang Military Command General HospitalUrumqi [42]Kashgar Prefecture Second People’s Hospital [43]Hainan Eye Hospital and Key Laboratory of Ophthalmology, ZhongshanOphthalmic Center, Sun Yat-sen University [44]The Affiliated Hospital of Guizhou Medical University [45]Tianjin medical university eye hospital [46]Ning Xia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region [47]Qinghai University Affiliated Hospital

出处：

DOI：

ISSN：

摘要：

To report three-decade changes of clinical characteristics, progress of treatments and risk factors associated for mortality and enucleation in patients with retinoblastoma in China.Retrospective cohort study METHODS: This multicenter study included 2552 patients diagnosed with retinoblastoma in 38 medical centers in 31 provinces in China from 1989 to 2017 with follow up data. Kendall's tau-b value was used to describe correlation coefficients between eras and clinical or demographic features. Hazard ratios and odds ratios were applied to measure risk factors.In this study, 324(13%) patients died of retinoblastoma and 1414(42%) eyes were removed. The 1-, 3-and 5- year disease-specific survival were 95%, 86% and 83%, respectively. Patients were diagnosed at a better stage by International Classification for Retinoblastoma over time (Kendall's tau-b value=-0.084, P<0.001). Pathological risk factors were also less observed in recent era. New conservative therapies were adopted and used in more patients. The eye removal rate gradually decreased (Kendall's tau-b value=-0.167, P<0.001). The disease-specific survival rate were 81%, 83% and 91% in the three eras. By multivariate cox regression, bilateral tumors and extraocular extension were risk factors for death. Among intraocular disease, group E indicated higher risk of mortality. By multivariate logistics regression, unilateral tumors, earlier era of diagnosis and extraocular extension were risk factors for eye salvage failure. Among intraocular retinoblastoma, groups D and E had higher risk of eye salvage failure.Patients were diagnosed at earlier stage in recent era. Conservative therapies including IAC were increasingly used. The above changes may contribute to the decreasing enucleation rate. Although no significant difference was identified in the mortality of the three eras, a decreasing trend was shown.Copyright © 2021. Published by Elsevier Inc.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 2 区

医学

小类 | 1 区眼科学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区眼科学

JCR分区：

出版当年[2020]版：

Q1 OPHTHALMOLOGY

最新[2023]版：

Q1 OPHTHALMOLOGY

影响因子： 4.1 最新[2023版] 4.4 最新五年平均 5.258 出版当年[2020版] 5.729 出版当年五年平均 4.013 出版前一年[2019版] 5.488 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTongUniversity School of Medicine, Shanghai, China

通讯作者：

通讯机构： [47]Qinghai University Affiliated Hospital [*1]Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No 639 Zhi Zao Ju Road, Shanghai 200011, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：