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Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling.

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收录情况： ◇ SCIE ◇ EI

作者：
Pan Shaojun[1,2,3] * ; Zhang Yuhui[4] ; Huang Mark[5] ; Deng Zhoufeng[6] ; Zhang Amin[2] ; Pei Lijia[3] ; Wang Lirui[2] ; Zhao Weiyong[6] ; Ma Lijun[6] ; Zhang Qian[2] ; Cui Daxiang[1,2,*1] ;
机构： [1]School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China [2]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, PR China [3]First Affiliated Hospital of Bengbu Medical College, Bengbu, 233030, China [4]Department of General Practice, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China [5]School of Electronic Information and Electrical Engineering, Shenzhen University, Shenzhen, 518061, China [6]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, PR China
出处：
DOI： 10.1016/j.biomaterials.2021.120946
ISSN：

摘要：
Multi-functional nanovectors based on exosomes from cancer cell culture supernatants in vitro has been successfully utilized for tumor-specific targeting and immune escape. However, the labor-intensive purification procedures for rich-dose and high-purity homogeneous exosomes without using targeting ligands are still a challenging task. Herein, we developed a nanovector Exo-PMA/Fe-HSA@DOX through cloaked by urinary exosome membrane as a chemo/chemodynamic theranostic nano-platform for targeted homologous prostate cancer therapy which pertain to the abrogation of Epidermal Growth Factor Receptor (EGFR) and its downstream AKT/NF-kB/IkB signaling instead of ERK signaling cascades. Urinary exosomes-based nanovectors own the same urological cancer cell membrane antigen inclusive of E-cadherin, CD 47 and are free from intracellular substance such as Histone 3 and COX Ⅳ. The targeting properties of the homologous cancer cell are well preserved in Exo-PMA/Fe-HSA@DOX nanovectors in high purity. Meanwhile, the nanovectors based on urinary exosomes from prostate patients deeply penetrated into prostate cancer DU145 3D MCTS, and successfully achieve superior synergistic low-dose chemo/chemodynamic performance in vivo. In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs). It is expected that the rich source and high purity of urinary exosomes offer a reliable solution for mass production of such nanovectors in the future. The targeted homologous cancer therapy based on the urinary exosomes from cancer patients exemplifies a novel targeted anticancer scheme with efficient and facile method.Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
National Key Research and Development Projects (2017YFA0205301 and 2016YFA0201200), International Cooperation and Exchanges Projects of National Natural Science Foundation of China (No. 82020108017), National Natural Science Foundation of China (No. 81903169), Innovative Team project of National Natural Science Foundation of China(No.81921002), Shanghai Sailing Program (No. 19YF1422300), Shanghai Jiao Tong University “Transformation Medicine Cross Research Fund” (ZH2018QNB25 and ZH2018QNB26), Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument (15DZ2252000) and China Postdoctoral Science Foundation (2020TQ0191).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 工程技术
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2019]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China [2]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, PR China [3]First Affiliated Hospital of Bengbu Medical College, Bengbu, 233030, China
通讯作者：
通讯机构： [1]School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China [2]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, PR China [*1]School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
推荐引用方式(GB/T 7714)：
Pan Shaojun,Zhang Yuhui,Huang Mark,et al.Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling.[J].BIOMATERIALS.2021,275:doi:10.1016/j.biomaterials.2021.120946.
APA：
Pan Shaojun,Zhang Yuhui,Huang Mark,Deng Zhoufeng,Zhang Amin...&Cui Daxiang.(2021).Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling..BIOMATERIALS,275,
MLA：
Pan Shaojun,et al."Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling.".BIOMATERIALS 275.(2021)

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