研究单位：[1]McMaster University[2]Population Health Research Institute[3]Canadian Institutes of Health Research (CIHR)[4]Canberra Hospital,Garran,Australian Capital Territory,Australia,2605[5]Concord Repatriation General Hospital,Concord,New South Wales,Australia,2139[6]Northern Beaches Hospital,Frenchs Forest,New South Wales,Australia,2086[7]Royal North Shore Hospital,Wahroonga,New South Wales,Australia,2076[8]Sydney Adventist Hospital,Wahroonga,New South Wales,Australia,2076[9]Sunshine Coast University Hospital,Birtinya,Queensland,Australia,4575[10]Royal Brisbane Women'[11]s Hospital,Herston,Queensland,Australia,4029[12]Princess Alexandra Hospital,Woolloongabba,Queensland,Australia,4102[13]Monash Health,Clayton,Victoria,Australia,3168[14]Western Health - Sunshine Hospital,Saint Albans,Victoria,Australia,3021[15]Clinica Senhor do Bonfim,Feira De Santana,Bahia,Brazil,44001-584[16]Clinica Senhor do Bonfim,Salvador,Bahia,Brazil,40415-065[17]Santa Casa de Misericordia de Belo Horizonte,Santa Efigênia,Belo Horizonte,Brazil,30150221[18]Medical School of Botucatu of the Paulista State University - UNESP,Rubiao Junior,Botucatu,Brazil,18618-687[19]Fundacao Pro-Rim,Boa Vista,Joinville,Brazil,89227680[20]Felicio Rocho Foundation - Hospital Felicio Rocho,Belo Horizonte,Minas Gerais,Brazil,30110934[21]Fundacao Hospitalar Sao Francisco de Assis,Belo Horizonte,Minas Gerais,Brazil,31110580[22]Servico Ubaense de Nefrologia Ltda,Uba,Minas Gerais,Brazil,36500008[23]Sociedade Hospitalar Angelina Caron,Campina Grande Do Sul,Parana,Brazil,83430000[24]Instituto Pro Renal Brazil,Curitiba,Parana,Brazil,80440-020[25]Irmandade da Santa Casa de Misericordia de Porto Alegre -ISCMPA,Bairro Santa Teresa,Porto Alegre,Brazil,90020090[26]Hospital de Clinicas de Porto Alegre,Porto Alegre,Rio Grande do Sul,Brazil,90035-903[27]Hospital Arquidiocesano Consul Carlos Reneaux,Brusque,Santa Catarina,Brazil,8835404[28]Sociedade Campineira de Educacao e Instrucao (SCEI),Campinas,Sao Paulo,Brazil,13034-685[29]Praxis Pesquisa Medica S/S,Santo André,Sao Paulo,Brazil,09090 790[30]Santa Casa de Misericordia de Votuporanga,Votuporanga,Sao Paulo,Brazil,15500003[31]PROCARDIO Clinica Cardiologica,Blumenau,South Carolina,Brazil,89010500[32]Hospital Alemao Oswaldo Cruz,Bela Vista,Brazil[33]Santa Casa de Misericordia de Ponta Grossa,Ponta Grossa,Brazil[34]Foothills Hospital,Calgary,Alberta,Canada,T2N 2T9[35]University of Alberta,Edmonton,Alberta,Canada,T6G 2G3[36]Royal Inland Hospital,Kamloops,British Colombia,Canada,V2C 2T1[37]Kelowna General Hospital,Kelowna,British Colombia,Canada,V1Y 1T2[38]St. Pauls Hospital,Vancouver,British Colombia,Canada,V6Z 1Y6[39]Penticton Regional Hospital,Penticton,British Columbia,Canada[40]Queen Elizabeth II Health Science Centre,Halifax,Nova Scotia,Canada,B3H 1V7[41]Cape Breton Regional Hospital,Sydney,Nova Scotia,Canada[42]St. Joseph''s Healthcare,Hamilton,Ontario,Canada,L8N 4A6[43]Queens University at Kingston General Hospital, Division of Nephrology,Kingston,Ontario,Canada[44]Victoria Hospital,London,Ontario,Canada,N6A 5W9[45]Ottawa Hospital Research Institute,Ottawa,Ontario,Canada,K1Y 4E9[46]Health Sciences North Research Institute,Sudbury,Ontario,Canada,P3E 5J1[47]St. Michael''s Hospital,Toronto,Ontario,Canada,M5B 1W8[48]St. Josephs, Toronto,Toronto,Ontario,Canada,M6R 1B5[49]Humber River Health,Toronto,Ontario,Canada[50]CIUSSS Hopital Maisonneuve- Rosemont,Montreal,Quebec,Canada,H1T 2M4[51]Hopital du Sacre-Coeur de Montreal,Montreal,Quebec,Canada,H4J 1C5[52]The Sir Mortimer B. Davis Jewish General Hospital,Montreal,Quebec,Canada[53]Centre Hospitalier de l'[54]Universite de Montreal (CHUM),Montréal,Quebec,Canada,H2W 1T8[55]CHU de Quebec L''Hotel-Dieu de Quebec,Québec,Quebec,Canada,G1R 2J6[56]Peking University First Hospital,Beijing,China[57]Peking University Peoples Hospital,Beijing,China[58]General Hospital of Ningxia Medical University,Yinchuan,Ningxia,China[59]Dezhou Peoples Hospital,Dezhou,Shandong,China[60]The First Affiliated Hospital of Baotou Medical College,Baotou,China[61]Beijing Miyun District Hospital,Beijing,China[62]Beijing Tongren Hospital, Capital Medical University,Beijing,China[63]Emergency General Hospital,Beijing,China[64]Faw General Hospital of Jilin Province,Changchun,China[65]The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,China[66]Huai''an First Peoples Hospital,Huai''an,China[67]The First Hospital of Kunming,Kunming,China[68]Gansu Baoshihua Hospital,Lanzhou,China[69]Yichuan County Traditional Chinese Medicine Hospital,Luoyang,China[70]Shanghai Tongji Hospital,Shanghai,China[71]Shanxi Provincial Peoples Hospital,Shanxi,China[72]Shuyang County Hospital of Traditional Chinese Medicine,Suqian,China[73]Sihong County Fenjinting Hospital,Suqian,China[74]Tianjin Fifth Central Hospital,Tianjin,China[75]Tianjin Third Central Hospital,Tianjin,China[76]Tongiao City Hospital,Tongliao,China[77]Xinxiang First Peoples Hospital,Xinxiang,China[78]General Hospital of Xuzhou Mining Group,Xuzhou,China
研究目的：
Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes high blood pressure and can damage the heart. Although spironolactone is very effective in patients that do not require dialysis, we do not know if spironolactone is effective in dialysis patients. Our research will help determine if spironolactone reduces heart failure and heart related deaths in dialysis patients. The purpose of this study is to determine if spironolactone reduces death or hospitalization for heart failure and is well tolerated in patients that require dialysis.
