研究单位：[1]Hoffmann-La Roche[2]Retinal Research Institute, LLC,Phoenix,Arizona,United States,85014[3]Associated Retina Consultants,Phoenix,Arizona,United States,85020[4]Northwest Arkansas Retina Associates,Springdale,Arkansas,United States,72762[5]California Retina Consultants,Bakersfield,California,United States,93309[6]Retina-Vitreous Associates Medical Group,Beverly Hills,California,United States,90211[7]The Retina Partners,Encino,California,United States,91436[8]Retina Consultants of Orange County,Fullerton,California,United States,92835[9]Northern California Retina Vitreous Associates,Mountain View,California,United States,94040[10]Retinal Consultants Med Group,Sacramento,California,United States,95825[11]California Retina Consultants,Santa Barbara,California,United States,93103[12]Bay Area Retina Associates,Walnut Creek,California,United States,94598[13]University of Colorado[14]dept of ophthalmology,Aurora,Colorado,United States,80045[15]Retina Consultants of Southern,Colorado Springs,Colorado,United States,80909[16]Retina Group of New England,Waterford,Connecticut,United States,06385[17]Retina Group of Florida,Fort Lauderdale,Florida,United States,33308[18]National Ophthalmic Research Institute,Fort Myers,Florida,United States,33912[19]Florida Eye Associates,Melbourne,Florida,United States,32901[20]Sunderland Eye Infirmary,Sunderland,United Kingdom,SR2 9HP[21]Bascom Palmer Eye Institute,Palm Beach Gardens,Florida,United States,33418[22]Fort Lauderdale Eye Institute,Plantation,Florida,United States,33324[23]Retina Vitreous Assoc of FL,Saint Petersburg,Florida,United States,33711[24]Southeast Retina Center,Augusta,Georgia,United States,30909[25]University Retina and Macula Associates, PC,Lemont,Illinois,United States,60439[26]Prairie Retina Center,Springfield,Illinois,United States,62704[27]Retina Specialists,Towson,Maryland,United States,21204[28]Tufts Medical Center[29]Ophthalmology,Boston,Massachusetts,United States,02111[30]Associated Retinal Consultants,Grand Rapids,Michigan,United States,49546[31]Vitreo-Retinal Associates,Grand Rapids,Michigan,United States,49546[32]Retina Consultants of Nevada,Las Vegas,Nevada,United States,89123[33]Envision Ocular, LLC,Bloomfield,New Jersey,United States,07003[34]Mid Atlantic Retina - Wills Eye Hospital,Cherry Hill,New Jersey,United States,08034[35]Long Is. Vitreoretinal Consult,Great Neck,New York,United States,11021[36]New York University,New York,New York,United States,10017[37]Ophthalmic Cons of Long Island,Oceanside,New York,United States,11572[38]Retina Assoc of Western NY,Rochester,New York,United States,14620[39]University of Rochester Flaum Eye Institute,Rochester,New York,United States,14642[40]The Retina Consultants,Slingerlands,New York,United States,12159[41]Cleveland Clinic Foundation[42]Cole Eye Institute,Cleveland,Ohio,United States,44195[43]Palmetto Retina Center,Florence,South Carolina,United States,29501[44]Retina Consultants Of Carolina,Greenville,South Carolina,United States,29605[45]Charleston Neuroscience Inst,Ladson,South Carolina,United States,29456[46]Southeastern Retina Associates Chattanooga,Chattanooga,Tennessee,United States,37421[47]Southeastern Retina Associates,Knoxville,Tennessee,United States,37923[48]Tennessee Retina PC,Nashville,Tennessee,United States,37203[49]Austin Retina Associates,Austin,Texas,United States,78705[50]Retina Consultants of Texas,Bellaire,Texas,United States,77401[51]Retina Center of Texas,Southlake,Texas,United States,76092[52]Univ of Virginia Ophthalmology,Charlottesville,Virginia,United States,22903[53]Retina Institute of Virginia,Richmond,Virginia,United States,23235[54]Retina Center Northwest,Silverdale,Washington,United States,98383[55]Organizacion Medica de Investigacion,Buenos Aires,Argentina,C1015ABO[56]Fundacion Zambrano,Caba,Argentina,C1017AAO[57]Oftalmos,Capital Federal,Argentina,C1120AAN[58]Oftar,Mendoza,Argentina,M5500GGK[59]Centro Oftalmólogos Especialistas,Rosario,Argentina,S2000ANJ[60]Grupo Laser Vision,Rosario,Argentina,S2000DLA[61]Strathfield Retina Clinic,Strathfield,New South Wales,Australia,2135[62]Sydney Eye Hospital,Sydney,New South Wales,Australia,2000[63]Sydney Retina Clinic and Day Surgery,Sydney,New South Wales,Australia,2000[64]Sydney West Retina,Westmead,New South Wales,Australia,2145[65]Centre For Eye Research Australia,East Melbourne,Victoria,Australia,3002[66]Retina Specialists Victoria,Rowville,Victoria,Australia,3178[67]The Lions Eye Institute,Nedlands,Western Australia,Australia,6009[68]Hospital de Olhos de Aparecida - HOA,Aparecida de Goiania,GO,Brazil,74980-010[69]Centro Brasileiro de Cirurgia,Goiania,GO,Brazil,74210-010[70]Hospital das Clinicas - UFRGS,Porto Alegre,RS,Brazil,90035-903[71]Botelho Hospital da Visao,Blumenau,SC,Brazil,89052-504[72]Faculdade de Medicina do ABC - FMABC,Santo Andre,SP,Brazil,09060-650[73]Universidade Federal de Sao Paulo - UNIFESP*X[74]Oftalmologia,Sao Paulo,SP,Brazil,04023-062[75]CEMAPE - Centro Médico,Sao Paulo,SP,Brazil,04084-002[76]Hospital das Clinicas - FMUSP,Sao Paulo,SP,Brazil,05403-900[77]Hosp de Olhos de Sorocaba,Sorocaba,SP,Brazil,18031-060[78]Calgary Retina Consultants,Calgary,Alberta,Canada,T2J 0C8[79]University of British Columbia - Vancouver Coastal Health Authority,Vancouver,British Columbia,Canada,V5Z 1M9[80]QEII - HSC Department of Ophthalmology,Halifax,Nova Scotia,Canada,B3H 2Y9[81]Vitreous Retina Macula Specialists of Toronto,Etobicoke,Ontario,Canada,M8X 2X3[82]Ivey Eye Institute,London,Ontario,Canada,N6A 4V2[83]University of Ottawa Eye Institute,Ottawa,Ontario,Canada,K1H 8L6[84]Toronto Retina Institute,Toronto,Ontario,Canada,M3C 0G9[85]Unity Health Toronto,Toronto,Ontario,Canada,M5B IW8[86]University Health Network Toronto Western Hospital,Toronto,Ontario,Canada,M5T 2S9[87]Institut De L'Oeil Des Laurentides,Boisbriand,Quebec,Canada,J7H 0E8[88]Hôpital Maisonneuve - Rosemont,Montreal,Quebec,Canada,H1T 2M4[89]Peking Union Medical College Hospital,Beijing City,China,100032[90]Beijing Friendship Hospital,Beijing,China,100050[91]Beijing Tongren Hospital,Beijing,China,100730[92]The Second Hospital of Jilin University,Changchun,China,130041[93]West China Hospital, Sichuan University,Chengdu,China,610041[94]Southwest Hospital , Third Military Medical University[95]Ophthalmology,Chongqing City,China,400014[96]Third Affiliated Hospital of Third Military Medical University[97]Ophthalmology,ChongQing,China,400000[98]Zhongshan Ophthalmic Center, Sun Yat-sen University,Guangzhou City,China,510060[99]The Affiliated Eye Hospital of Nanjing Medical University,Nanjing City,China,210029[100]Shanghai Tenth People's Hospital,Shanghai,China,200072[101]Shanghai First People's Hospital,Shanghai,China,200080[102]Tianjin Eye Hospital,Tianjin City,China,300050[103]Tianjin Medical University Eye Hospital,Tianjin City,China,300070[104]Eye Hospital, Wenzhou Medical University,Wenzhou City,China,325027[105]Wuxi No.2 People's Hospital,Wuxi,China,214000[106]FN Hradec Králové, Oční klinika[107]Ophthalmology clinic,Hradec Králové,Czechia,500 05[108]Faculty Hospital Ostrava[109]Ophthalmology clinic,Ostrava,Czechia,708 52[110]Faculty Hospital Kralovske Vinohrady[111]Ophthalmology clinic,Prague,Czechia,100 34[112]AXON Clinical,Prague,Czechia[113]Nemocnice Sokolov,Sokolov,Czechia,356 01[114]Aalborg Universitetshospital[115]Øjenafdelingen,Aalborg,Denmark,9000[116]Rigshospitalet Glostrup[117]Afdeling for Øjensygdomme, Center for Forskning,Glostrup,Denmark,2600[118]Sjællands Universitetshospital, Roskilde[119]Øjenafdelingen,Roskilde,Denmark,4000[120]Chi De Creteil[121]Ophtalmologie,Creteil,France,94010[122]CHU Bocage[123]Ophtalmologie,Dijon,France,21079[124]Hopital de la croix rousse[125]Ophtalmologie,Lyon cedex,France,69317[126]CHNO des Quinze Vingts[127]Ophtalmologie,Paris,France,75012[128]Centre Ophtalmologique[129]Imagerie et laser,Paris,France,75015[130]Centres Ophtalmologique St Exupéry[131]Ophtalmologie,St Cyr Sur Loire,France,37540[132]Hôpital PURPAN - CHU TOULOUSE[133]Ophtalmologie,Toulouse,France,31059[134]Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Augenheilkunde,Dresden,Germany,01307[135]Universitätsklinikum Freiburg, Klinik für Augenheilkunde,Freiburg,Germany,79106[136]Universitätsklinikum des Saarlandes[137]Klinik für Augenheilkunde,Homburg/Saar,Germany,66424[138]Universitätsklinikum Magdeburg A.ö.R., Universitätsaugenklinik,Magdeburg,Germany,39120[139]LMU Klinikum der Universität, Augenklinik,München,Germany,80336[140]Klinikum rechts der Isar der TU München[141]Augenklinik,München,Germany,81675[142]Universitätsklinikum Würzburg, Augenklinik und Poliklinik,Würzburg,Germany,97080[143]Queen Mary Hospital[144]Department of Ophthalmology,Hong Kong,Hong Kong[145]Hong Kong Eye Hospital[146]CUHK Eye Centre,Mongkok,Hong Kong[147]Magyar Honvedseg Egeszsegugyi Kozpont[148]Szemészeti Osztály,Budapest,Hungary,1068[149]Peterfy Sandor utcai Korhaz-Rendelointezet es Baleseti Kozpont, Szemeszet KR,Budapest,Hungary,1076[150]Semmelweis Egyetem Szemészeti Vizsgálóhely,Budapest,Hungary,1085[151]Bajcsy-Zsilinszky Hospital,Budapest,Hungary,1106[152]Fondazione Ptv Policlinico Tor Vergata Di Roma[153]U.O.S.D. Patologie Renitiche,Roma,Lazio,Italy,00133[154]ASST FATEBENEFRATELLI SACCO[155]Oculistica (Sacco),Milano,Lombardia,Italy,20157[156]Azienda Ospedaliero-Universitaria Careggi[157]S.O.D. Oculistica,Firenze,Toscana,Italy,50134[158]Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello[159]U.O. Oculistica Universitaria,Pisa,Toscana,Italy,56124[160]Ospedale Classificato Equiparato Sacro Cuore - Don Calabria[161]Dipartimento Oculistica,Negrar - Verona,Veneto,Italy,37024[162]A.O. Universitaria S. Maria Della Misericordia Di Udine[163]Clinica Oculistica,Udine,Veneto,Italy,33100[164]Seoul National University Bundang Hospital,Seongnam-si,Korea, Republic of,13605[165]Kyung Hee University Hospital,Seoul,Korea, Republic of,02447[166]Seoul National University Hospital,Seoul,Korea, Republic of,03080[167]Samsung Medical Center,Seoul,Korea, Republic of,06351[168]Asan Medical Center.,Seoul,Korea, Republic of,138-736[169]OFTALMIKA Sp. Z o.o,Bydgoszcz,Poland,85-631[170]Specjalistyczny Ośrodek Okulistyczny Oculomedica,Bydgoszcz,Poland,85-870[171]Optimum Profesorskie Centrum Okulistyki,Gdańsk,Poland,80-809[172]Poradnia Okulistyczna I Salon Optyczny w Gliwicach- PRYZMAT,Gliwice,Poland,44-100[173]SP ZOZ Szpital Uniwersytecki w Krakowie Oddział Kliniczny Okulistyki I Onkologii Okulistycznej,Krakow,Poland,31-501[174]Osrodek Chirurgii Oka prof. Zagorskiego Rzeszow,Rzeszów,Poland,35-017[175]Caminomed,Tarnowskie Góry,Poland,42-600[176]Centrum Zdrowia MDM,Warszawa,Poland,00-631[177]Hospital de Braga[178]Servico de Oftalmologia,Braga,Portugal,4710-243[179]AIBILI - Association for Innovation and Biomedical Research on Light,Coimbra,Portugal,3000-548[180]Espaco Medico Coimbra,Coimbra,Portugal,3030-163[181]Hospital de Santa Maria[182]Servico de Oftalmologia,Lisboa,Portugal,1649-035[183]Intersec Research and Technology Complex "Eye Microsurgery" n.a. S.N. Fyodorov[184]Cheboksary Branch,Cheboksary,Marij EL,Russian Federation,428000[185]Clinics of Eye Diseases, LLC,Kazan,Tatarstan,Russian Federation,420066[186]"Intersec. Research and Technology Complex "Eye Microsurgery" n a Fyodorov Irkutsk branch,Irkutsk,Russian Federation,664033[187]"Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch,Novosibirsk,Russian Federation,630096[188]National University Hospital[189]Ophthalmology Department,Singapore,Singapore,119074[190]Singapore Eye Research Institute,Singapore,Singapore,168751[191]Tan Tock Seng Hospital[192]Ophthalmology Department,Singapore,Singapore,308433[193]Instituto Oftalmologico Fernandez Vega[194]Servicio de oftalmologia,Oviedo,Asturias,Spain,33012[195]Hospital Universitario de Bellvitge,Hospitalet de Llobregat,Barcelona,Spain,08907[196]Hospital General de Catalunya,San Cugat Del Valles,Barcelona,Spain,08195[197]Complejo Hospitalario de Navarra[198]Servicio de oftalmologia,Pamplona,Navarra,Spain,31008[199]Oftalvist Valencia,Burjassot,Valencia,Spain,46100[200]Institut de la Macula I la retina,Barcelona,Spain,08022[201]Hospital dos de maig[202]Pharmacy Service,Barcelona,Spain,08025[203]Hospital Clinico San Carlos[204]Servicio de oftalmologia,Madrid,Spain,28040[205]Clinica Baviera[206]Servicio Oftalmologia,Madrid,Spain,28046[207]Fisabio-Ofalmologia Medica[208]Servicio de Oftalmología,Valencia,Spain,46015[209]Hospital Universitario Rio Hortega[210]Servicio de Oftalmologia,Valladolid,Spain,47012[211]Vista Klinik Ophthalmologische Klinik,Binningen,Switzerland,4102[212]Taipei Veterans General Hospital[213]Ophthalmology,Taipei,Taiwan,11217[214]Chang Gung Medical Foundation - Linkou[215]Ophthalmology,Taoyuan,Taiwan,333[216]National Taiwan University Hospital[217]Ophthalmology,Zhongzheng Dist.,Taiwan,10002[218]King Chulalongkorn Memorial Hospital[219]Ophthalmology Department,Bangkok,Thailand,10330[220]Rajavithi Hospital[221]Ophthalmology Department,Bangkok,Thailand,10400[222]Maharaj Nakorn ChiangMai Hospital[223]Ophthalmology Department,ChiangMai,Thailand,50200[224]Ankara University Medical Faculty[225]Department of Ophthalmology,Ankara,Turkey,06340[226]Ankara Baskent University Medical Faculty[227]Department of Ophthalmology,Ankara,Turkey,06490[228]Beyoglu Goz Training and Research Hospital[229]Department Of Ophthalmology,Istanbul,Turkey,34421[230]Kocaeli Üniversitesi Tıp Fakültesi[231]Department of Ophthalmology,Kocaeli,Turkey,41380[232]Barnet Hospital[233]ROYAL FREE LONDON NHS FOUNDATION TRUST,Barnet,United Kingdom,EN5 3DJ[234]Belfast Health and Social Care Trust, ROYAL VICTORIA HOSPITAL,Belfast,United Kingdom,BT12 6BA[235]Bradford Royal Infirmary,Bradford,United Kingdom,BD9 6RJ[236]University Hospitals Bristol NHS Foundation Trust, Bristol Eye Hospital,Bristol,United Kingdom,BS1 2LX[237]East Kent Hospitals University NHS Foundation Trust,Canterbury,United Kingdom,CT1 3NG[238]Frimley Park Hospital,Frimley,United Kingdom,GU16 7UJ[239]Gloucestershire Hospitals NHS Foundation Trust,Gloucestershire,United Kingdom,GL1 3NN[240]St James University Hospital,Leeds,United Kingdom,LS9 7TF[241]Royal Liverpool University Hospital[242]St Paul's Clinical Eye Research Centre,Liverpool,United Kingdom,L7 8XP[243]Moorfields Eye Hospital NHS Foundation Trust,London,United Kingdom,EC1V 2PD[244]Royal Free Hospital,London,United Kingdom,NW3 2QS[245]Kings College Hospital,London,United Kingdom,SW9 8RR[246]Manchester Royal Eye Hospital,Manchester,United Kingdom,M13 9WL[247]Hillingdon Hospital,Middx,United Kingdom,UB8 3NN[248]Royal Victoria Infirmary,Newcastle upon Tyne,United Kingdom,NE1 4LP[249]James Paget University Hospitals NHS Foundation Trust,Norfolk,United Kingdom,NR31 6LA[250]University Hospital Southampton NHS Foundation Trust[251]Southampton Eye Unit,Southampton,United Kingdom,SO16 6YD
研究目的：
This study will evaluate the efficacy, safety, and pharmacokinetics of faricimab administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W), in participants with diabetic macular edema (DME).
