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A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)

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研究单位: [1]Hoffmann-La Roche [2]Department of Ophthalmology,Izmir,Turkey,35100 [3]Associated Retina Consultants,Phoenix,Arizona,United States,85020 [4]Arizona Retina and Vitreous Consultants,Phoenix,Arizona,United States,85021 [5]Northern California Retina Vitreous Associates,Mountain View,California,United States,94040 [6]Retinal Consultants Med Group,Sacramento,California,United States,95825 [7]Orange County Retina Med Group,Santa Ana,California,United States,92705 [8]California Retina Consultants,Santa Barbara,California,United States,93103 [9]Colorado Retina Associates, PC,Lakewood,Colorado,United States,80228 [10]Retina Group of Florida,Fort Lauderdale,Florida,United States,33308 [11]Retina Care Specialists,Palm Beach Gardens,Florida,United States,33410 [12]Southern Vitreoretinal Assoc,Tallahassee,Florida,United States,32308 [13]Retina Associates of Florida, LLC,Tampa,Florida,United States,33609 [14]Southeast Retina Center,Augusta,Georgia,United States,30909 [15]Georgia Retina PC,Marietta,Georgia,United States,30060-1137 [16]Retina Consultants of Hawaii,'Aiea,Hawaii,United States,96701 [17]University Retina and Macula Associates, PC,Oak Forest,Illinois,United States,60452 [18]Prairie Retina Center,Springfield,Illinois,United States,62704 [19]Raj K. Maturi, MD PC,Indianapolis,Indiana,United States,46290 [20]Wolfe Eye Clinic,West Des Moines,Iowa,United States,50266 [21]Maine Eye Center,Portland,Maine,United States,04101 [22]The Retina Care Center,Baltimore,Maryland,United States,21209 [23]Cumberland Valley Retina PC,Hagerstown,Maryland,United States,21740 [24]Retina Specialists,Towson,Maryland,United States,21204 [25]Ophthalmic Consultants of Boston,Boston,Massachusetts,United States,02114 [26]VitreoRetinal Surgery, PLLC. [27]DBA Retina Consultants of Minnesota,Edina,Minnesota,United States,55435 [28]Island Retina,Shirley,New York,United States,11967 [29]Retina Assoc of Cleveland Inc,Cleveland,Ohio,United States,44122 [30]The Ohio State University Havener Eye Institute,Columbus,Ohio,United States,43212 [31]Midwest Retina,Dublin,Ohio,United States,43016 [32]Mid Atlantic Retina - Wills Eye Hospital,Philadelphia,Pennsylvania,United States,19107 [33]Palmetto Retina Center,West Columbia,South Carolina,United States,29169 [34]Southeastern Retina Associates Chattanooga,Chattanooga,Tennessee,United States,37421 [35]Retina Res Institute of Texas,Abilene,Texas,United States,79606 [36]Austin Retina Associates,Austin,Texas,United States,78705-1169 [37]Austin Clinical Research LLC,Austin,Texas,United States,78750 [38]Retina Specialists,DeSoto,Texas,United States,75115 [39]Retina Center of Texas,Southlake,Texas,United States,76092 [40]Retina Consultants of Houston,The Woodlands,Texas,United States,77384 [41]Strategic Clinical Research Group, LLC,Willow Park,Texas,United States,76087 [42]Retina Associates of Utah,Salt Lake City,Utah,United States,84107 [43]Piedmont Eye Center,Lynchburg,Virginia,United States,24502 [44]Wagner Macula & Retina Center,Norfolk,Virginia,United States,23502 [45]Retina Center Northwest,Silverdale,Washington,United States,98383 [46]Fundacion Zambrano,Caba,Argentina,C1017AAO [47]Centro Oftalmológico Dr. Charles S.A.,Capital Federal,Argentina,C1015ABO [48]Oftalmos,Capital Federal,Argentina,C1120AAN [49]Buenos Aires Mácula,Ciudad Autonoma Buenos Aires,Argentina,C1061AAE [50]Oftar,Mendoza,Argentina,M5500GGK [51]Grupo Laser Vision,Rosario,Argentina,S2000DLA [52]Organizacion Medica de Investigacion,San Nicolás,Argentina,C1015ABO [53]Eyeclinic Albury Wodonga,Albury,New South Wales,Australia,2640 [54]Marsden Eye Research Centre,Parramatta,New South Wales,Australia,2150 [55]Strathfield Retina Clinic,Strathfield,New South Wales,Australia,2135 [56]Sydney Eye Hospital,Sydney,New South Wales,Australia,2000 [57]Sydney Retina Clinic and Day Surgery,Sydney,New South Wales,Australia,2000 [58]Sydney West Retina,Westmead,New South Wales,Australia,2145 [59]Centre For Eye Research Australia,East Melbourne,Victoria,Australia,3002 [60]Retina Specialists Victoria,Rowville,Victoria,Australia,3178 [61]The Lions Eye Institute,Nedlands,Western Australia,Australia,6009 [62]LKH-Univ.Klinikum Graz [63]Universitäts-Augenklinik,Graz,Austria,8036 [64]Medizinische Universität Wien [65]Universitätsklinik für Augenheilkunde und Optometrie,Wien,Austria,1090 [66]Hospital de Olhos de Aparecida - HOA,Aparecida de Goiania,GO,Brazil,74980-010 [67]Universidade Federal de Sao Paulo - UNIFESP*X [68]Oftalmologia,Sao Paulo,SP,Brazil,04023-062 [69]Pentagram Eye Hospital (Medical Center "Pentagram"),Sofia,Bulgaria,1309 [70]Specialized Hospital for Active Treatment of Eye Diseases Zora,Sofia,Bulgaria,1784 [71]Peking Union Medical College Hospital,Beijing City,China,100032 [72]Beijing Friendship Hospital,Beijing,China,100050 [73]Beijing Tongren Hospital,Beijing,China,100730 [74]The Second Hospital of Jilin University [75]ophthalmology department,Changchun City,China,130041 [76]West China Hospital, Sichuan University,Chengdu,China,610041 [77]Southwest Hospital , Third Military Medical University [78]Ophthalmology,Chongqing City,China,400014 [79]Daping Hospital of Third Military Medical University,Chongqing,China,400042 [80]Zhongshan Ophthalmic Center, Sun Yat-sen University,Guangzhou City,China,510060 [81]The Second Affiliated Hospital of Harbin Medical University [82]ophthalmology department,Harbin,China,150081 [83]The Affiliated Eye Hospital of Nanjing Medical University,Nanjing City,China,210029 [84]Shanghai First People's Hospital,Shanghai,China,200080 [85]He Eye Specialist Shenyang Hospital,Shenyang City,China,110034 [86]Tianjin Eye Hospital,Tianjin City,China,300050 [87]Eye Hospital, Wenzhou Medical University,Wenzhou City,China,325027 [88]Wuxi No.2 People's Hospital,Wuxi,China,214000 [89]Rigshospitalet Glostrup [90]Afdeling for Øjensygdomme, Center for Forskning,Glostrup,Denmark,2600 [91]Sjællands Universitetshospital, Roskilde [92]Øjenafdelingen,Roskilde,Denmark,4000 [93]Chi De Creteil [94]Ophtalmologie,Creteil,France,94010 [95]Pole Vision Val d'Ouest [96]Ophtalmologie,Ecully,France,69130 [97]Hopital de la croix rousse [98]Ophtalmologie,Lyon cedex,France,69317 [99]Centre Paradis Monticelli [100]Ophtalmologie,Marseille,France,13008 [101]CHU Nantes - Hôtel Dieu [102]Ophthalmology,Nantes,France,44093 [103]Centre Odeon [104]Exploration Ophtalmologique,Paris,France,75006 [105]Hopital Lariboisiere [106]Ophtalmologie,Paris,France,75010 [107]Centre Ophtalmologique [108]Imagerie et laser,Paris,France,75015 [109]Centres Ophtalmologique St Exupéry [110]Ophtalmologie,St Cyr Sur Loire,France,37540 [111]Universitätkslinikum Düsseldorf, Augenklinik [112]Klinik fürAugenheilkunde,Düsseldorf,Germany,40225 [113]Universitätsklinikum Köln [114]Augenklinik,Köln,Germany,50937 [115]Augenabteilung am St. Franziskus-Hospital,Münster,Germany,48145 [116]Universitätsklinikum Münster [117]Augenheilkunde,Münster,Germany,48149 [118]Queen Mary Hospital [119]Department of Ophthalmology,Hong Kong,Hong Kong [120]Hong Kong Eye Hospital [121]CUHK Eye Centre,Mongkok,Hong Kong [122]Magyar Honvedseg Egeszsegugyi Kozpont [123]Szemészeti Osztály,Budapest,Hungary,1068 [124]Bajcsy-Zsilinszky Hospital,Budapest,Hungary,1106 [125]Szegedi Tudományegyetem ÁOK [126]Department of Ophtalmology,Szeged,Hungary,6720 [127]Fondazione Ptv Policlinico Tor Vergata Di Roma [128]U.O.S.D. Patologie Renitiche,Roma,Lazio,Italy,00133 [129]UNIVERSITA' DEGLI STUDI DI GENOVA - Di.N.O.G. [130]CLINICA OCULISTICA,Genova,Liguria,Italy,16132 [131]ASST FATEBENEFRATELLI SACCO [132]Oculistica (Sacco),Milano,Lombardia,Italy,20157 [133]Azienda Ospedaliero-Universitaria Careggi [134]S.O.D. Oculistica,Firenze,Toscana,Italy,50134 [135]Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello [136]U.O. Oculistica Universitaria,Pisa,Toscana,Italy,56124 [137]A.O. Universitaria S. Maria Della Misericordia Di Udine [138]Clinica Oculistica,Udine,Veneto,Italy,33100 [139]Pusan National University Hospital,Busan,Korea, Republic of,602-739 [140]Yeungnam University Medical Center,Daegu,Korea, Republic of,42415 [141]Seoul National University Bundang Hospital,Seongnam-si,Korea, Republic of,13620 [142]Kyung Hee University Hospital,Seoul,Korea, Republic of,02447 [143]Seoul National University Hospital,Seoul,Korea, Republic of,03080 [144]Nune Eye Hospital [145]Ophthalmology,Seoul,Korea, Republic of,06192 [146]Samsung Medical Center,Seoul,Korea, Republic of,135-710 [147]Asan Medical Center.,Seoul,Korea, Republic of,5505 [148]OFTALMIKA Sp. Z o.o,Bydgoszcz,Poland,85-631 [149]Optimum Profesorskie Centrum Okulistyki,Gdańsk,Poland,80-809 [150]SP ZOZ Szpital Uniwersytecki w Krakowie Oddział Kliniczny Okulistyki I Onkologii Okulistycznej,Krakow,Poland,31-501 [151]Caminomed,Tarnowskie Góry,Poland,42-600 [152]Hospital de Braga [153]Servico de Oftalmologia,Braga,Portugal,4710-243 [154]Centro Hospitalar E Universitário de Coimbra EPE - Serviço Oftalmologia [155]Serviço Oftalmologia,Coimbra,Portugal,3000-075 [156]Hospital de Sao Joao [157]Servico de Oftalmologia,Porto,Portugal,4200-319 [158]Intersec Research and Technology Complex "Eye Microsurgery" n.a. S.N. Fyodorov [159]Cheboksary Branch,Cheboksary,Marij EL,Russian Federation,428000 [160]"Intersec. Research and Technology Complex "Eye Microsurgery" n a Fyodorov Irkutsk branch,Irkutsk,Russian Federation,664033 [161]"Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch,Novosibirsk,Russian Federation,630096 [162]1 Saint-Petersburg St. Med. University named after academician I.P.Pavlov [163]Chair of ophathalmology,Saint Petersburg,Russian Federation,197022 [164]National University Hospital [165]Ophthalmology Department,Singapore,Singapore,119074 [166]Singapore Eye Research Institute,Singapore,Singapore,168751 [167]Instituto Oftalmologico Fernandez Vega [168]Servicio de oftalmologia,Oviedo,Asturias,Spain,33012 [169]Hospital Universitario de Bellvitge,Hospitalet de Llobregat,Barcelona,Spain,08907 [170]Institut de la Macula I la retina,Barcelona,Spain,08022 [171]Hospital Clinic de Barcelona [172]Consultas Externas Oftalmologia,Barcelona,Spain,08028 [173]Hospital Universitario Rio Hortega [174]Servicio de Oftalmologia,Valladolid,Spain,47012 [175]Hospital Universitario Miguel Servet [176]Servicio de Oftalmologia,Zaragoza,Spain,50009 [177]Changhua Christian Hospital [178]Department of Ophthalmology,Changhua,Taiwan,500 [179]Taipei Veterans General Hospital [180]Ophthalmology,Taipei,Taiwan,11217 [181]Chang Gung Medical Foundation - Linkou [182]Ophthalmology,Taoyuan,Taiwan,333 [183]Hacettepe University Medical Faculty [184]Department of Ophthalmology,Ankara,Turkey,06100 [185]Ankara University Medical Faculty [186]Department of Ophthalmology,Ankara,Turkey,06340 [187]Gazi University Faculty of Medicine [188]Department Of Ophthalmology,Ankara,Turkey,06560 [189]Ege University Medical Faculty

关键词: AMD nAMD neovascular age-related macular degeneration choroidal neovascularization secondary to age-related macular degeneration

研究目的:
This study will evaluate the efficacy, safety, durability, and pharmacokinetics of faricimab administered at intervals as specified in the protocol, compared with aflibercept once every 8 weeks (Q8W), in participants with neovascular age-related macular degeneration (nAMD).

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