研究单位：[1]Loxo Oncology, Inc.[2],Spain,8035[3]University of Alabama at Birmingham,Birmingham,Alabama,United States,35233[4]Royal Marsden Hospital,Sutton,Surrey,United Kingdom,SM2 5PT[5]City of Hope National Medical Center,Duarte,California,United States,91010-0269[6]UCLA Medical Center,Los Angeles,California,United States,90095[7]University of California, Davis - Health Systems,Sacramento,California,United States,95817[8]Los Angeles Biomedical Research Institute at Harbor - UCLA Medical,Torrance,California,United States,90502[9]Emory University,Atlanta,Georgia,United States,30322[10]University of Chi Med Center,Chicago,Illinois,United States,60637[11]Massachusetts General Hospital,Boston,Massachusetts,United States,02114[12]University of Michigan,Ann Arbor,Michigan,United States,48109[13]Memorial Sloan Kettering Cancer Center,New York,New York,United States,10017[14]Sidney Kimmel Ctr. For Urologic & Prostate Cancers, MSKCC,New York,New York,United States,10065[15]University of Cincinnati Cancer Institute,Cincinnati,Ohio,United States,45267[16]Ohio State University Medical Center,Columbus,Ohio,United States,43210[17]University of Pennsylvania Hospital,Philadelphia,Pennsylvania,United States,19104[18]University of Texas MD Anderson Cancer Center,Houston,Texas,United States,77030[19]University of Wisconsin-Madison Hospital and Health Clinic,Madison,Wisconsin,United States,53792-4108[20]Royal North Shore Hospital,St. Leonards,New South Wales,Australia,2065[21]Peter MacCallum Cancer Centre,Melbourne,Victoria,Australia,3000[22]The Alfred Hospital,Melbourne,Victoria,Australia,3004[23]Sir Charles Gairdner Hospital,Nedlands,Western Australia,Australia,6009[24]Universitair Ziekenhuis Antwerpen,Edegem,Belgium,2650[25]Centre Hospitalier Universitaire Sart Tilman,Liege,Belgium,4000[26]Oncocentro,Belo Horizonte,Minas Gerais,Brazil,30380-680[27]Hospital de Cancer de Londrina,Londrina,Paraná,Brazil,86015-520[28]Hospital de Clinicas de Porto Alegre,Porto Alegre,Rio Grande Do Sul,Brazil,90035-003[29]Instituto de Educação, Pesquisa e Gestão em Saúde,Rio de Janeiro,RJ,Brazil,22793-080[30]Fundação Pio XII - Hospital de Câncer de Barretos,Barretos,Sao Paulo,Brazil,14784-400[31]Hospital PUC-CAMPINAS,Campinas,São Paulo,Brazil,13060-904[32]Hospital das Clinicas da FMRP,Ribeirão Preto,São Paulo,Brazil,14051-140[33]INCA Hospital do Câncer III,Rio de Janeiro,Brazil,20560-120[34]Oncoclinicas Rio de Janeiro S.A.,Rio de Janeiro,Brazil,22250-905[35]Soc. Beneficente de Senhoras Hospital Sirio Libanes-Oncology,Sao Paolo,Brazil,01308-050[36]Icesp - Instituto Do Câncer Do Estado de São Paulo,Sao Paulo,Brazil,01246000[37]Centro Paulista de Oncologia,São Paulo,Brazil,04538-133[38]Clinica Onco Star,São Paulo,Brazil,04543-000[39]London Health Science Centre - Victoria Hospital,London,Ontario,Canada,N6A 5W9[40]Princess Margaret Hospital (Ontario),Toronto,Ontario,Canada,M5G 2M9[41]Anhui Provincial Hospital,Hefei,Anhui,China,230001[42]Beijing Tongren Hospital affiliated to Capital Medical Unive,Beijing,China,100730[43]The First Affiliated Hospital of Fujian Medical University,Fujian,Fuzhou,China,350005[44]Gansu Province Cancer Hospital,Lanzhou,Gansu,China,730050[45]Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,China,510060[46]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,150081[47]Henan Cancer Hospital,Zhengzhou,Henan,China,450008[48]Hunan Cancer Hospital,Changsha,Hunan,China,410013[49]Jilin Cancer Hospital,Chang Chun,Ji Lin,China,130012[50]Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu,China,210000[51]Jinan Central Hospital,Jinan,Shandong,China,250013[52]Fudan University Shanghai Cancer Center,Shanghai,Shanghai,China,200032[53]West China Hospital of Sichuan University,Cheng Du,Sichuan,China,610041[54]First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,650032[55]Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang,China,310014[56]Sir Run Run Shaw Hospital,Hangzhou,Zhejiang,China,310016[57]Zhejiang Cancer Hospital,Hangzhou,Zhejiang,China,310022[58]Chongqing Cancer Hospital,Chongqing,China,400030[59]Tianjin Medical University Cancer Institute and Hospital,Tianjin,China,300060[60]Fakultni nemocnice Brno,Brno,Czechia,62500[61]Fakultni nemocnice Olomouc,Olomouc,Czechia,779 00[62]Fakultni Nemocnice v Motole,Praha 5,Czechia,150 06[63]Assistance Publique Hôpitaux de Marseille - Hôpital Nord,Marseille,Bouches-du-Rhône,France,13915[64]Centre Georges François Leclerc,Dijon,Côte-d'Or,France,21079[65]Centre Hospitalier Universitaire d'Angers,Angers,Maine-et-Loire,France,49933[66]Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne,Clermont-Ferrand,Puy-de-Dôme,France,63011[67]Centre Leon Berard,Lyon,Rhône-Alpes,France,69008[68]Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest,Bordeaux,France,33076[69]Centre François Baclesse,Caen Cedex 5,France,14076[70]Hôpital C. HURIEZ,Lille,France,59037[71]Hopital Pitie Salpetriere -Unité Thyroïde-Tumeurs Endocrines,PARIS- cedex 13,France,765651[72]Institut de cancérologie Strasbourg Europe,Strasbourg,France,67386[73]Institut Claudius Regaud,Toulouse cedex 9,France,31059[74]Gustave Roussy,Villejuif Cedex,France,94805[75]Klinikum der Universität München Großhadern,München,Bayern,Germany,81377[76]Universitätsklinikum Würzburg A. ö. R.,Würzburg,Bayern,Germany,97080[77]Medizinische Hochschule Hanover,Hannover,Niedersachsen,Germany,30625[78]Universitätsmedizin Johannes Gutenberg Universität Mainz,Mainz,Rheinland-Pfalz,Germany,55131[79]Charité Campus Mitte,Berlin,Germany,10117[80]Universitaetsklinikum Essen,Essen,Germany,45147[81]Studiengesellschaft Hämato-Onkologie Hamburg - Prof Laack & Partner,Hamburg,Germany,20251[82]Otto-von-Guericke-Universität,Magdeburg,Germany,39120[83]Alexandra General Hospital of Athens,Athens,Attikí,Greece,11528[84]University General Hospital of Heraklion,Heraklion,Krítí,Greece,711 10[85]European Interbalkan Medical Center,Thessaloniki,Thessaloníki,Greece,570 01[86]Regional Cancer Centre,Trivandrum,Kerala,India,695011[87]HCG Manavata Cancer Centre,Nashik,Maharashtra,India,422001[88]Ruby Hall Clinic and Grant Medical Foundation,Pune,Maharashtra,India,411001[89]Deenanath Mangeshkar Hospital & Research Centre,Pune,Maharashtra,India,411004[90]Apollo Gleneagles Hospitals Kolkata,Kolkata,West Bengal,India,700054[91]Postgraduate Institute of Medical Education & Research,Chandigarh,India,160012[92]Hadassah Medical Center,Jerusalem,Israel,9112001[93]Rabin Medical Center,Petach Tikva,Israel,4941492[94]Sheba Medical Center,Ramat Gan,Israel,5265602[95]Istituto Nazionale dei Tumori,Milano,Lombardie,Italy,20133[96]Ospedale San Luca, IRCCS Istituto Auxologico,Milano,Milan,Italy,20149[97]Polic.Umberto I -Univ. La Sapienza,Roma,Rome,Italy,00161[98]A.O.U. Senese Policlinico Santa Maria alle Scotte,Siena,SI,Italy,53100[99]Istituto Oncologico Veneto IRCCS,Padova,Veneto,Italy,35128[100]Ospedale Garibaldi-Nesima,Catania,Italy,95122[101]Azienda Ospedaliera Universitaria Federico II,Napoli,Italy,80131[102]Azienda Ospedlaliero-Univeristaria Pisana, Stabilimento Ospedaliero di Cisanello,Pisa,Italy,56125[103]I.F.O. Istituto Nazionale Tumori Regina Elena,Roma,Italy,00144[104]Azienda Ospedaliero-Universitaria S.Giovanni Battista,Torino,Italy,10126[105]Aichi Cancer Center Hospital,Nagoya,Aichi,Japan,464-8681[106]National Cancer Center Hospital East,Kashiwa,Chiba,Japan,277-8577[107]Hokkaido University Hospital,Sapporo,Hokkaido,Japan,060-8648[108]Kobe University Hospital,Kobe,Hyogo,Japan,650-0017[109]Yokohama City University Hospital,Yokohama,Kanagawa,Japan,236-0004[110]Osaka University Hospital,Suita,Osaka,Japan,565-0871[111]Japanese Foundation for Cancer Research,Koto,Tokyo,Japan,135-8550[112]National Hospital Organization Kyushu Medical Center,Fukuoka,Japan,810 8563[113]National Cancer Center,Goyang-si,Gyeonggi-do,Korea, Republic of,10408[114]Seoul National University Bundang Hospital,Seongnam-si,Gyeonggi-do,Korea, Republic of,13620[115]Chonnam National University Hwasun Hospital,Hwasun-gun,Jeollanam Do,Korea, Republic of,58128[116]Seoul National University Hospital,Seoul,Seoul, Korea,Korea, Republic of,03080[117]Severance Hospital, Yonsei University Health System,Seoul,Korea, Republic of,03722[118]Samsung Medical Center,Seoul,Korea, Republic of,06351[119]Nederlands Kanker Instituut - Antoni van Leeuwenhoek,Amsterdam,Netherlands,1066 CX[120]University Medical Center Groningen,Groningen,Netherlands,9713 GZ[121]Leids Universitair Medisch Centrum,Leiden,Netherlands,2333 ZA[122]Maastricht UMC+,Maastricht,Netherlands,6229 HX[123]Erasmus Medisch Centrum,Rotterdam,Netherlands,3015 GD[124]Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie,Gliwice,Poland,44 102[125]Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej,Kielce,Poland,25-734[126]National medical research center of radiology Obninsk,Obninsk,Kaluga Region,Russian Federation,249036[127]Clinic of advanced medical technologies n. a. Nicolay I. Pirogov (policlinic, hospital),Saint-Petersburg,Northwestern Federal District,Russian Federation,190020[128]LLC Evimed,Chelyabinsk,Russian Federation,454048[129]Blokhin Cancer Research Center,Moscow,Russian Federation,115478[130]National Medical Research Center of Endocrinology of Ministry of Health Dept,Moscow,Russian Federation,117036[131]Saint-Petersburg City Clinical Oncology Dispensary,Saint-Petersburg,Russian Federation,198255[132]Hospital Universitario Virgen de la Victoria,Malaga,Andalucia,Spain,29010[133]Hospital Universitari de Girona Dr. Josep Trueta,Girona,Barcelona,Spain,17007[134]Hospital Universitario Ramón y Cajal,Madrid,Madrid, Comunidad De,Spain,28034[135]Clinica Universidad de Navarra,Pamplona,Navarra,Spain,31008[136]Clinica Universitaria De Navarra,Pamplona,Navarra,Spain,31008[137]Institut Catala d'Oncologia,Barcelona,Spain,08908[138]Hospital General Universitario Gregorio Marañon,Madrid,Spain,28007[139]Hospital Clinico San Carlos,Madrid,Spain,28040[140]Hospital Universitario 12 de Octubre,Madrid,Spain,28041[141]Hospital Universitario La Paz,Madrid,Spain,28046[142]Hospital Universitario Miguel Servet,Zaragoza,Spain,50009[143]China Medical University Hospital,Taichung,Taiwan,40447[144]National Cheng Kung University Hospital,Tainan,Taiwan,704[145]National Taiwan University Hospital,Taipei,Taiwan,10048[146]Gartnavel General Hospital,Glasgow,Glasgow City,United Kingdom,G12OYN[147]University College Hospital - London,London,Greater London,United Kingdom,NW1 2PG[148]Royal Marsden NHS Trust,London,Greater London,United Kingdom,SW3 6JJ[149]Velindre Cancer Centre,Cardiff,South Glamorgan,United Kingdom,CF14 2TL[150]Weston Park Hospital,Sheffield,South Yorkshire,United Kingdom,S10 2SJ
The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have the option to potentially crossover to selpercatinib.
