研究单位:[1]Hoffmann-La Roche[2]Chugai Pharmaceutical[3]Neurology,Samsun,Turkey,55139[4]HonorHealth Neurology,Scottsdale,Arizona,United States,85251[5]Keck School of Medicine of USC,Los Angeles,California,United States,90033[6]University of California Irvine - Manchester Pavilion,Orange,California,United States,92868[7]SC3 Research Group, Inc,Pasadena,California,United States,91105[8]Medical Faculty Associates Inc.,Washington,District of Columbia,United States,20037[9]University of Florida Jacksonville Physicians Inc. (UFJPI),Jacksonville,Florida,United States,32209[10]University of Chicago Hospital,Chicago,Illinois,United States,60637[11]Prairie Education and Research,O'Fallon,Illinois,United States,62269[12]University of Iowa Hospitals & Clinics[13]Department of Neurology,Iowa City,Iowa,United States,52242[14]Massachusetts General Hospital,Boston,Massachusetts,United States,02114-2621[15]Washington University School of Medicine[16]Department of Neurology,Saint Louis,Missouri,United States,63110[17]University at Buffalo / SUNY[18]UBMD Neurology,Buffalo,New York,United States,14203[19]South Shore Neurologic Associates P.C.,Patchogue,New York,United States,11772[20]NeuroScience Research Center,Canton,Ohio,United States,44718[21]The Ohio State University Wexner Medical Center[22]Department of Neurology,Columbus,Ohio,United States,43221[23]Hospital Italiano[24]Neurology,Caba,Argentina,C1199ABA[25]Hospital Ramos Mejía,Caba,Argentina,C1221ADC[26]Hospital Britanico,Ciudad Autonoma Bs As,Argentina,C1280AEB[27]Fundación Scherbovsky[28]General Department,Mendoza,Argentina,M5500AYB[29]INECO Neurociencias Orono,Rosario,Argentina,S2000DTC[30]Centro de Investigaciones Médicas Tucuman[31]REUMATHOLOGY,San Miguel,Argentina,T4000AXL[32]Concord Repatriation General Hospital,Concord,New South Wales,Australia,2139[33]Princess Alexandra Hospital,Woolloongabba,Queensland,Australia,4102[34]Box Hill Hospital[35]Department of Neurology,Box Hill,Victoria,Australia,3128[36]Instituto de Neurologia de Curitiba,Curitiba,PR,Brazil,81210-310[37]Hospital Sao Lucas - PUCRS,Porto Alegre,RS,Brazil,90610-000[38]Hospital das Clinicas - UNICAMP,Campinas,SP,Brazil,13083-887[39]Faculdade de Medicina do ABC - FMABC,Santo Andre,SP,Brazil,09060-650[40]Hospital Sao Paulo,Sao Paulo,SP,Brazil,04037-002[41]MUCH - Montreal Neurological Institute & Hospital,Montreal,Quebec,Canada,H3A 2B4[42]Beijing Tiantan Hospital,Capital Medical University,Beijing City,China,100050[43]Beijing Tongren Hospital,Beijing,China,100730[44]The First Hospital of Jilin University,Changchun City,China,130021[45]Hunan Children's Hospital,Changsha City,China,410007[46]Xiangya Hospital Central South University,Changsha City,China,410008[47]West China Hospital - Sichuan University,Chengdu City,China,610047[48]The Affiliated Hospital of Guizhou Medical University,Guiyang City,China,550000[49]Sir Run Run Shaw Hospital,Hangzhou City,China,310018[50]The First Affiliated Hospital Of Shandong First Medical University,Jinan City,China,250014[51]Huashan Hospital, Fudan University,Shanghai City,China,200040[52]Children's Hospital of Fudan University,Shanghai,China,201102[53]Tianjin Medical University General Hospital,Tianjin,China,300052[54]The First Affiliated Hospital of Wenzhou Medical University,Wenzhou City,China,325035[55]Tongji Hospital Tongji Medical College Huazhong University of Science and Technology,Wuhan City,China,430030[56]Tangdu Hospital,Xi'an City,China,710038[57]Aarhus Universitetshospital[58]Neurologisk Klinik,Aarhus N,Denmark,8200[59]Rigshospitalet[60]Klinik for Nerve- og Muskelsygdomme,København Ø,Denmark,2100[61]APHP Raymond Poincare,Garches,France,92380[62]Hopital Timone Adultes[63]Neurologie Mal Neuro Musculaires,Marseille,France,13385[64]CHU de Nantes - Hotel Dieu,Nantes,France,44093[65]CHU Nice - Hôpital Pasteur 2[66]SYST NERVEUX PERIPHERIQUE MUSCLE,Nice,France,06000[67]CHU Bordeaux,Pessac,France,33604[68]St. Josef-Hospital, Klinik für Neurologie,Bochum,Germany,44791[69]Universitätsklinikum Essen (AöR)[70]Klinik für Neurologie,Essen,Germany,45147[71]Univeristätsklinikum Leipzig[72]Klinik und Poliklinik für Neurologie,Leipzig,Germany,04103[73]Universitätsklinikum Münster[74]Klinik und Poliklinik für Neurologie,Münster,Germany,48149[75]Azienda Ospedaliera A. Cardarelli[76]Dipartimento medico polispecialistico,Napoli,Campania,Italy,80131[77]A.O. Sant'Andrea[78]UOC Neurologia, Dip. Di Neuroscienze, Salute Mentale e Organi di Senso (NESMOS),Roma,Lazio,Italy,00189[79]Fond. Istituto Neurologico C.Besta[80]UO Neurologia IV - Neuroimmunologia Malattie Neuromuscolari,Milano,Lombardia,Italy,20133[81]Fondazione Istituto Neurologico Mondino IRCCS[82]SC Neuroncologia e neuroinfiammazione,Pavia,Lombardia,Italy,27100[83]A.R.N.A.S. Civico Di Cristina Benfratelli[84]U.O.C. Neurologia con Stroke Unit,Palermo,Sicilia,Italy,90127[85]Ospedale Cà Foncello[86]S.C Neurologia,Treviso,Veneto,Italy,31100[87]Juntendo University Hospital[88]Neurology,Bunkyo-ku,Japan,113-8431[89]Chiba University Hospital[90]Neurology,Chiba-shi, Chiba,Japan,260-8677[91]General Hanamaki Hospital[92]Neurology,Hanamaki, Iwate,Japan,025-0082[93]Hiroshima University Hospital,Hiroshima,Japan,734-8551[94]Sapporo Medical University Hospital[95]Neurology,Hokkaido,Japan,060-8543[96]NHO Hokkaido Medical Center,Hokkaido,Japan,063-0005[97]Kagawa University Hospital[98]Neurology,Kagawa,Japan,761-0793[99]St. Marianna University Hospital,Kanagawa,Japan,216-8511[100]Saitama Medical Center[101]Neurology,Kawagoe-shi, Saitama,Japan,350-8550[102]Nagasaki Kawatana Medical Center[103]Neurology,Nagasaki,Japan,859-3615[104]International University of Health and Welfare Narita Hospital[105]Neurology,Narita, Chiba,Japan,286-0124[106]Kindai University Hospital[107]Neurology,Osaka,Japan,589-8511[108]Osaka Toneyama Medical Center[109]Neurology,Osaka,Japan[110]Dokkyo Medical University Saitama Medical Center[111]Neurology,Saitama,Japan,343-8555[112]Tokyo Women's Medical University Hospital[113]Neurology,Shinjuku-ku,Japan,162-8666[114]Seirei Hamamatsu General Hospital,Shizuoka,Japan,430-8558[115]Osaka University Hospital[116]Neurology,Suita,Japan,565-0871[117]Tokyo Medical And Dental University, Medical Hospital[118]Neurology,Tokyo,Japan,113-8519[119]Tokyo Medical University Hospital,Tokyo,Japan,160-0023[120]Kyungpook National University Chilgok Hospital,Daegu,Korea, Republic of,41404[121]Pusan National University Yangsan Hospital,Gyeongsangnam-do,Korea, Republic of,50612[122]Severance Hospital, Yonsei University Health System,Seoul,Korea, Republic of,003-722[123]Korea University Anam Hospital,Seoul,Korea, Republic of,02841[124]Samsung Medical Center,Seoul,Korea, Republic of,135-710[125]Amsterdam UMC Location AMC,Amsterdam,Netherlands,1105 AZ[126]LUMC,Leiden,Netherlands,2333 ZA[127]Klinika Neurologii Doros?ych, Uniwersyteckie Centrum Kliniczne,Gda?sk,Poland,80-952[128]Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K,Krakow,Poland,31-505[129]Zespol Poradni Specjalistycznych - Poradnia Neurologiczna[130]Szpital Uniwersytecki w Krakowie,Kraków,Poland,31-503[131]FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency,Krasnoyarsk,Krasnojarsk,Russian Federation,660037[132]Krasnoyarsk State Medical Academy,Krasnoyarsk,Krasnojarsk,Russian Federation,660049[133]National Center of Social Significant Disease,Sankt-peterburg,Leningrad,Russian Federation,197110[134]Novosibirsk State Regional Clinical Hospital,Novosibirsk,Russian Federation,630087[135]Leningrad Regional Clinical Hospital,St Petersburg,Russian Federation,194291[136]Hospital Universitari de Bellvitge[137]Servicio de Neurologia,L'Hospitalet de Llobregat,Barcelona,Spain,08907[138]Hospital de Donostia Unidad Demencias[139]Consultas de Neurología,San Sebastian,Guipuzcoa,Spain,20080[140]Hospital Universitario Infanta Sofia[141]Servicio de Neurologia,San Sebastian de los Reyes,Madrid,Spain,28702[142]Clinica Universitaria de Navarra[143]Servicio de Neurología,Pamplona,Navarra,Spain,31008[144]Hospital de la Santa Creu I Sant Pau[145]Servicio de Neurologia,Barcelona,Spain,08041[146]Hospital General Universitario Gregorio Marañon[147]Servicio de Neurologia,Madrid,Spain,28007[148]Clinica Universitaria Navarra[149]Servicio Neurologia,Madrid,Spain,28027[150]Hospital Universitario la Fe[151]Servicio de Neurologia,Valencia,Spain,46026[152]Taipei Veterans General Hospital-Neurology,Taipei,Taiwan,11217[153]Chang Gung Medical Foundation Linkou Branch,Taoyuan City,Taiwan,333[154]Hacettepe University Medical Faculty[155]Neurology,Ankara,Turkey,06100[156]Ege University Medical Faculty,Izmir,Turkey,35100[157]Kocaeli University Hospital[158]Department of Neurology,Kocaeli,Turkey,41380[159]Ondokuz Mayis Univ. Med. Fac.
研究目的:
This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab compared with placebo in participants with generalized myasthenia gravis (gMG).