A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
研究单位：[1]Janssen Research & Development, LLC[2]Mission Cancer Blood,Des Moines,Iowa,United States,50309[3]Cancer And Hematology Centers of Western Michigan PC,Grand Rapids,Michigan,United States,49503[4]Royal Prince Alfred Hospital,Camperdown,Australia,2050[5]Barwon Health - University Hospital Geelong,Geelong,Australia,3220[6]Liverpool Hospital,Liverpool,Australia,2170[7]Sir Charles Gairdner Hospital,Nedlands,Australia,6009[8]Calvary Mater Newcastle Hospital,New South Wales,Australia,2298[9]Wollongong Hospital,Wollongong,Australia,2500[10]Princess Alexandra Hospital,Woolloongabba,Australia,4102[11]Ordensklinikum Linz GmbH Elisabethinen,Linz,Austria,4020[12]SCRI CCCIT gem GmbH,Salzburg,Austria,5020[13]Medical University Vienna,Vienna,Austria,1090[14]Hanusch Krankenhaus,Wien,Austria,1140[15]Institut Jules Bordet,Anderlecht,Belgium,1070[16]Ghent University Hospital,Gent,Belgium,9000[17]Jolimont,Haine Saint Paul La Louviere,Belgium,7100[18]Az Groeninge,Kortrijk,Belgium,8500[19]Universitair Ziekenhuis Leuven,Leuven,Belgium,3000[20]GZA Ziekenhuizen- Campus St Augustinus,Wilrijk,Belgium,2610[21]Fundacao Pio XII,Barretos,Brazil,14784 400[22]Santa Casa de Misericordia de Belo Horizonte,Belo Horizonte,Brazil,30150 320[23]Liga Paranaense de Combate ao Cancer,Curitiba,Brazil,81520 060[24]Instituto Do Cancer Do Ceara,Fortaleza,Brazil,60430-230[25]Liga Norte Riograndense Contra O Cancer,Natal,Brazil,59062-000[26]Complexo Hospitalar de Niteroi,Niteroi,Brazil,24030-103[27]Hospital De Clinicas De Porto Alegre,Porto Alegre,Brazil,90035 903[28]Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP,Ribeirao Preto,Brazil,14051-140[29]Hospital Sao Rafael,Salvador,Brazil,41235-190[30]Hospital Nove de Julho,Sao Paulo,Brazil,01409-902[31]Clinica Medica Sao Germano S/S LTDA,Sao Paulo,Brazil,04537-081[32]Hospital Das Clinicas Da Faculdade De Medicina Da USP,Sao Paulo,Brazil,05403 000[33]Arthur J E Child Comprehensive Cancer Centre,Calgary,Alberta,Canada,T2N 5G2[34]Cross Cancer Institute,Edmonton,Alberta,Canada,T6G 1Z2[35]British Columbia Cancer Agency,Vancouver,British Columbia,Canada,V5Z4E6[36]CHU de Quebec L Hotel Dieu de Quebec,Quebec,Canada,G1J 1Z4[37]Peking University First Hospital,Beijing,China,100034[38]Beijing Tongren Hospital CMU,Beijing,China,100051[39]Changzhou No 2 Peoples Hospital,Chang Zhou,China,213004[40]The First Hospital of Jilin University,Changchun,China,130061[41]The Second Xiangya Hospital of Central South Hospital,Changsha,China,410011[42]Beijing Chaoyang Hospital,Chaoyang District,China,100020[43]Sichuan Provincial Peoples Hospital,Chengdu,China,610072[44]Chongqing University Cancer Hospital,Chongqing,China,400030[45]Fujian Meidical University Union Hospital,Fu Zhou,China,350001[46]Nanfang Hospital,Guangzhou,China,510515[47]Sun Yat -Sen University Cancer Center,Guangzhou,China,511363[48]The Second Affiliated Hospital of Zhejiang University,Hang Zhou,China,310003[49]No.1 Affiliated Hospital, Medical College of Zhejiang University,Hangzhou,China,310003[50]Harbin medical university cancer hospital,Harbin,China,150081
研究目的：
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
