研究单位：[1]Sun Yat-sen University[2]First People's Hospital of Foshan[3]Third Affiliated Hospital, Sun Yat-Sen University[4]The First Affiliated Hospital of Anhui Medical University[5]Anhui Provincial Cancer Hospital[6]Dongguan People's Hospital[7]Beijing Tongren Hospital[8]Anhui Provincial Hospital[9]Peking University Third Hospital[10]Henan Cancer Hospital[11]Ganzhou Cancer Hospital[12]Guangzhou Chest Hospital.[13]First Affiliated Hospital of Jinan University[14]Peking University Shenzhen Hospital[15]Affiliated Cancer Hospital & Institute of Guangzhou Medical University[16]Sun Yat-sen university cancer center,Guangzhou,Guangdong,China,510060
This study aims to initially utilize machine learning on pan-cancer DNA methylation data from public databases to construct a DNA methylation classification model (PaCIFiC-CUP, pan-cancer integrated fingerprinting classifier of CUP) for diagnosing various types of cancer, particularly the primary site of cancer of unknown primary. The goal is to achieve diagnosis of cancer pathology type by analyzing the DNA methylation patterns of cancer specimens, thereby guiding subsequent precision treatment for cancer.
