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The Ocular Glymphatic System—Current Understanding and Future Perspectives

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收录情况： ◇ SCIE

作者：

机构： [1] Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark [2] Center for Translational Neuromedicine, University of Rochester Medical Center, Elmwood Avenue 601, Rochester, NY 14642, USA [3] Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94117, USA

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关键词： glymphatic–lymphatic fluid transport perivascular spaces aquaporin-4 intraocular pressure intracranial pressure meningeal lymphatics amyloid-beta cerebrospinal fluid blood–retinal barrier glaucoma diabetes

摘要：

The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.

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出版当年[2022]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MULTIDISCIPLINARY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 4.9 最新[2023版] 5.6 最新五年平均 5.6 出版当年[2022版] 6.2 出版当年五年平均 6.208 出版前一年[2021版] 4.9 出版后一年[2023版]

第一作者：

第一作者机构： [1] Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark

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通讯作者：

通讯机构： [1] Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark [2] Center for Translational Neuromedicine, University of Rochester Medical Center, Elmwood Avenue 601, Rochester, NY 14642, USA

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