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Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells

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机构： [1]Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, 89 French St, New Brunswick, NJ 08901 USA [2]Rutgers Robert Wood Johnson Med Sch, Grad Sch Biomed Sci, New Brunswick, NJ 08901 USA [3]Rutgers Robert Wood Johnson Med Sch, Dept Pediat, New Brunswick, NJ 08901 USA [4]Sun Yat Sen Univ, State Key Lab Ophthalmol, Guangdong Key Lab Ophthalmol & Visual Sci, Guangzhou, Guangdong, Peoples R China

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关键词： YIN-YANG 1 T-CELLS NEGATIVE SELECTION THYMOCYTE SURVIVAL ZINC-FINGER REGULATOR LINEAGE PROTEIN MICE YIN-YANG-1

摘要：

The promyelocytic leukemia zinc-finger transcription factor (PLZF) is essential for nearly all of the unique, innate-like functions and characteristics of NKT cells. It is not known, however, if the activity of PLZF is regulated by other factors. In this article, we show that the function of PLZF is completely dependent on the transcription factor Yin Yang 1 (YY1). Mouse NKT cells expressing wild-type levels of PLZF, but deficient for YY1, had developmental defects, lost their characteristic "preformed" mRNA for cytokines, and failed to produce cytokine protein upon primary activation. Immunoprecipitation experiments showed that YY1 and PLZF were coassociated. Taken together, these biochemical and genetic data show that the broadly expressed transcription factor, YY1, is required for the cell-specific "master regulator" functions of PLZF.

基金：

基金编号： AI059739 P30CA072720 67038 R01 AI083988

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出版当年[2018]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区免疫学

JCR分区：

出版当年[2017]版：

Q2 IMMUNOLOGY

最新[2023]版：

Q2 IMMUNOLOGY

影响因子： 3.6 最新[2023版] 4.2 最新五年平均 4.539 出版当年[2017版] 4.99 出版当年五年平均 4.856 出版前一年[2016版] 4.718 出版后一年[2018版]

第一作者：

第一作者机构： [1]Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, 89 French St, New Brunswick, NJ 08901 USA

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通讯机构： [1]Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, 89 French St, New Brunswick, NJ 08901 USA [*1]Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, 89 French St, New Brunswick, NJ 08901 USA

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