机构：[1]Eye School of Chengdu University of TCM, In eye Hospital of Chengdu University of TCM, Chengdu, China,[2]Beijing Ming Vision and Ophthalmology, Dongcheng District, Beijing, China,[3]Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose To quantitatively evaluate outcomes after small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism. Methods It's a retrospective cohort study. Twenty-four eyes of 15 patients with more than 0.75 diopters (D) of astigmatism in hyperopic eyes were enrolled in this study. The hyperopic eye with astigmatism was first treated with SMILE to correct astigmatism; then a lenticule was extracted from a donor myopic eye and subsequently implanted into the hyperopic eye with astigmatism. Patients were examined preoperatively and 1 day, 1 week, 1,3 months and 1 year after surgery. The main outcome measures were the uncorrected and corrected distance visual acuity (UDVA and CDVA), uncorrected near visual acuity (UNVA), spherical equivalent (SE), corneal topography, anterior segment optical coherence topography (OCT) and ocular response analyzer (ORA) parameters: corneal hysteresis (CH) and corneal resistance factor (CRF). Repeated-measures analyses of variance (ANOVA) and post hoc tests were used to analyze data of different follow-up visits. Results The mean preoperative cylinder was 1.951.04(D). The UDVA (from 0.37 +/- 0.23 to 0.09 +/- 0.09), UNVA (from 0.49 +/- 0.21 to 0.08 +/- 0.06), SE (from +7.42 +/- 3.12 to -0.75 +/- 0.79) and astigmatism (+1.95 +/- 1.04 to -0.65 +/- 0.63) postoperatively were obviously better than those before surgery. Five eyes (26.3%) gained one line of CDVA, and 3 eyes (15.8%) gained two lines of CDVA one year after surgery compared with preoperative levels. The average corneal curvature was changed from (43.19 +/- 4.37) D to (49.19 +/- 3.87) D one year after surgery. The anterior segment OCT images of corneas with lenticule inlays at each follow-up visit showed that the implanted lenticule was shaped like a crescent in the corneal stroma. The CH and CRF didn't change significantly after surgery (p = 0.189 and p = 0.107respectively). Conclusions SMILE combined with intrastromal lenticule inlay can be used to correct high hyperopia with astigmatism with good safety, efficacy and reproducibility.
基金：
Beijing Municipal Administration of Hospitals Clinical medicine Development of special foundation [XMLX201614]; Beijing Municipal Education Commission Science and Technology Key Project [KZ201710025021]; Beijing Ming Vision and Ophthalmology is an affiliated teaching clinic for Eye School of Chengdu University of TCM
第一作者机构：[1]Eye School of Chengdu University of TCM, In eye Hospital of Chengdu University of TCM, Chengdu, China,[2]Beijing Ming Vision and Ophthalmology, Dongcheng District, Beijing, China,[3]Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Eye School of Chengdu University of TCM, In eye Hospital of Chengdu University of TCM, Chengdu, China,[2]Beijing Ming Vision and Ophthalmology, Dongcheng District, Beijing, China,[3]Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Zhang Jing,Zhou Yuehua.Small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism[J].PLOS ONE.2021,16(9):doi:10.1371/journal.pone.0257667.
APA：
Zhang, Jing&Zhou, Yuehua.(2021).Small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism.PLOS ONE,16,(9)
MLA：
Zhang, Jing,et al."Small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism".PLOS ONE 16..9(2021)
