机构：[1]Hongqiao International Institue of Medicine & Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
The high mobility group box 1 (HMGB1) is a potential biomarker and therapeutic target in various human diseases. However, a systematic, comprehensive pan-cancer analysis of HMGB1 in human cancers remains to be reported. This study analysed the genetic alteration, RNA expression profiling and DNA methylation of HMGB1 in more than 30 types of tumours. It is worth noting that HMGB1 is overexpressed in malignant tissues, including lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), pancreatic adenocarcinoma (PAAD) and thymoma (THYM). Interestingly, there is a positive correlation between the high expression of HMGB1 and the high survival prognosis of THYM. Finally, this study comprehensively evaluates the genetic variation of HMGB1 in human malignant tumours. As a prospective biomarker of COVID-19, the role that HMGB1 plays in THYM is highlighted.
基金：
Shanghai
Municipal Human Resource Bureau
and Shanghai Science and Technology
Committee (Pujiang Talent Program grant
numbers, No. 19PJC085).
第一作者机构：[1]Hongqiao International Institue of Medicine & Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[*1]Hongqiao International Institue of Medicine & Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
通讯作者：
通讯机构：[1]Hongqiao International Institue of Medicine & Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[*1]Hongqiao International Institue of Medicine & Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
推荐引用方式(GB/T 7714)：
Yu Shoukai,Qian Lingmei,Ma Jun.Genetic alterations, RNA expression profiling and DNA methylation of HMGB1 in malignancies[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2022,26(15):4322-4332.doi:10.1111/jcmm.17454.
APA：
Yu, Shoukai,Qian, Lingmei&Ma, Jun.(2022).Genetic alterations, RNA expression profiling and DNA methylation of HMGB1 in malignancies.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,26,(15)
MLA：
Yu, Shoukai,et al."Genetic alterations, RNA expression profiling and DNA methylation of HMGB1 in malignancies".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 26..15(2022):4322-4332
