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Outcomes of Microcatheter-assisted Trabeculotomy for Glaucoma Associated with Sturge-Weber Syndrome and Phakomatosis Pigmentovascularis

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机构： [1]Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [2]Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [3]Department of Mathematics, Beijing University of Chemical Technology, Beijing, China [4]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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To evaluate mid-term efficacy and safety of ab externo microcatheter-assisted trabeculotomy (MAT) for early-onset glaucoma associated with Sturge-Weber syndrome (SWS) and phakomatosis pigmentovascularis (PPV).Retrospective, non-comparative, interventional case series.Medical records of consecutive SWS or PPV associated glaucoma patients who had undergone ab externo MAT between August 2017 and April 2020 at Beijing Children's hospital were reviewed. Success was defined as an intraocular pressure (IOP) of lower than 21 mmHg with (qualified success) or without (complete success) the use of antiglaucoma medication.Overall, 13 eyes (12 patients) with SWS and 9 eyes (8 patients) with PPV were included, with a mean age of 12.8±15.8 months at the time of surgery and a mean follow-up time of 39.5±10.4 months. Both the SWS (26.5±5.3 mmHg at baseline vs. 16.5±5.0 mmHg at the last visit, P<0.001) and PPV (29.2±7.5 mm Hg vs. 23.4±4.7mmHg, P=0.014) subsets achieved a statistically significant fall in IOP following surgery. Kaplan-Meier survival rate of complete(qualified) success after 42 months was 76.2% (87.5%) and 22.2% (40.0%) for eyes with SWS and PPV, respectively. Complications were minimal. PPV was associated with worse surgical outcomes.Ab externo MAT is an effective and safe treatment for early-onset glaucoma associated with SWS, but a gradual increase of IOP over time was noted in some patients. Ab externo MAT has limited efficacy for early-onset glaucoma associated with PPV in the mid-term.Copyright © 2022. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 1 区

医学

小类 | 1 区眼科学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区眼科学

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出版当年[2021]版：

Q1 OPHTHALMOLOGY

最新[2024]版：

Q1 OPHTHALMOLOGY

影响因子： 4.2 最新[2024版] 4.3 最新五年平均 5.488 出版当年[2021版] 6.048 出版当年五年平均 5.258 出版前一年[2020版] 4.2 出版后一年[2022版]

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第一作者机构： [1]Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

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通讯机构： [1]Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [4]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China [*1]Beijing Children’s Hospital, 56 Nanlishi Road, Xicheng District, Beijing 100045, China [*2]Beijing Tongren Hospital, 8 Chongwenmennei Street, Dongcheng District, Beijing 100005, China

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