To explore the therapeutic effect, safety, and economic benefit of a "one-stop" diagnosis and treatment mode of vascular surgery for ischemic diabetic foot ulcer, and to analyze the associated and independent factors that affect ulcer healing.In a prospective, single-center study, patients with ischemic diabetic foot ulcers from January 2017 to July 2021 were treated with either percutaneous endovascular angioplasty combined with negative pressure closed drainage (PTA-VSD) or percutaneous endovascular angioplasty combined with depuration (PTA-UD). The effectiveness and economic benefits of the two measures were compared, and independent factors affecting ulcer healing were explored via univariate and logistic regression analyses.Fifty patients with ischemic diabetic foot ulcer (25 patients in the PTA-VSD group and 25 patients in the PTA-UD group; 40 males and 10 females) were included, with an average age of 67.74±10.71 years. No difference was observed in the demographic data. The findings showed that the ulcer healing time in the PTA-VSD group was significantly shorter than that in the PTA-UD group (154.79 vs 238.31 days), and the ulcer healing rate at 180 days post-surgery was significantly greater in the PTA-VSD group (52% vs 12%) (p=0.002, < 0.05). The ulcer score in the PTA-VSD group decreased significantly at 3,6, and 12 months post-surgery. The duration of hospitalization in the PTA-VSD group was greater (P =0.002, < 0.05), but no significant difference in hospitalization frequency and cost was observed between the two groups. During follow-up, there was one death and one amputation in the PTA-UD group, but no death or amputation in the PTA-VSD group. Arterial occlusion was primarily located in the femoral-popliteal artery and the inferior knee artery in the two groups, and PTA intervention effectively opened the outflow tract of the affected limb. Two to three outflow tracts were opened in 41 patients. The ABI after surgery was significantly higher in both groups than before. Univariate and multivariate logistic regression analyses revealed that the Wagner grade and number of outflow channels and therapies (PTA-VSD) could be independent factors affecting ulcer healing.The severity of diabetic foot ulcers is an important factor affecting the quality of life of patients. A multidisciplinary "one-stop" treatment strategy based on percutaneous endovascular angioplasty combined with negative pressure sealing drainage can rapidly and effectively restore the blood flow to the affected limb and promote ulcer healing without increasing medical costs.Copyright © 2022. Published by Elsevier Inc.