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Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1

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机构： [1]Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [2]Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Department of Gastrointestinal Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

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Pancreatic cancer (PC) is an aggressive malignancy with poor prognosis. Accumulating studies have showed that long non-coding RNA (lncRNA) is a crucial regulator in various tumorigenesis and progression including PC. This research aims to explore the roles and molecular mechanism of lncRNA cancer susceptibility candidate 9 (CASC9) in PC.The expression levels of lncRNA CASC9 and miR-497-5p were evaluated in PC tissues and paired adjacent healthy tissues by quantitative real-time PCR. PC cell lines were transfected with lentivirus targeting lncRNA CASC9, and cells proliferation, migration and invasion tests were conducted. Dual luciferase reporter assays were also carried out to explore the relationship between lncRNA CASC9, miR-497-5p and Cyclin D1 (CCND1).LncRNA CASC9 was significantly up-regulated in PC tissues, while miR-497-5p expression was down-regulated. Down-regulation of lncRNA CASC9 in PC cells can significantly suppress the cell aggressiveness both in vitro and in vivo; moreover, knock-down of miR-497-5p could neutralize this impact. Additionally, the luciferase activity assay has assured that CCND1 was a downstream target of miR-497-5p.LncRNA CASC9 can promote the PC progression by modulating miR-497-5p/CCND1 axis, which is potential target for PC treatment.© 2023 Wiley Periodicals LLC.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 2 区水资源 3 区毒理学 3 区环境科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区环境科学 3 区毒理学 3 区水资源

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出版当年[2021]版：

Q2 ENVIRONMENTAL SCIENCES Q2 TOXICOLOGY Q2 WATER RESOURCES

最新[2024]版：

Q2 ENVIRONMENTAL SCIENCES Q2 TOXICOLOGY Q2 WATER RESOURCES

影响因子： 3.2 最新[2024版] 3.5 最新五年平均 4.109 出版当年[2021版] 3.747 出版当年五年平均 4.119 出版前一年[2020版] 4.5 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [2]Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

通讯作者：

通讯机构： [1]Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [*1]Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

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