OBJECTIVE: The aim of the study was to investigate the clinical value of the Global Registry of Arterial Events in Acute Coro-nary Syndromes (GRACE) score combined with the D-dimer/fibrinogen ratio (DFR) in predict-ing the short-term prognosis of patients under-going percutaneous coronary intervention (PCI) early after thrombolysis for acute myocardial in-farction (AMI).PATIENTS AND METHODS: A total of 102 patients who underwent PCI early after throm-bolysis for AMI during April 2020 to January 2022 in our hospital were picked as study sub-jects. These subjects were assigned as the good prognosis group (without adverse car-diovascular events) and poor prognosis group (with adverse cardiovascular events) accord-ing to whether adverse cardiovascular events occurred during hospitalization and follow-up. Changes in GRACE scores and DFR levels in pa-tients with different prognoses were analyzed. The GRACE score and DFR level of patients with different prognosis were analyzed. The clinic pathological characteristics were collected, and the risk factors for poor prognosis of AMI pa-tients were analyzed by logistic risk regression; ROC curve was used to analyze the prognos-tic value of GRACE score combined with DFR in early PCI patients after AMI thrombolysis.RESULTS: Compared with the good progno-sis group, the GRACE score and DFR level in the poor prognosis group were much high -er (p<0.001). Significant differences existed in blood pressure, ejection fraction, number of diseased branches, and Killip grading be-tween the patients with good prognosis and those with poor prognosis (p<0.05). There exist-ed no significant difference in clinical medica-tion between the patients with good prognosis and those with poor prognosis (p>0.05). Logis-tic multivariate analysis indicated that GRACE score, DFR, ejection fraction, number of lesion branches, and Killip grade were all risk factors influencing the prognosis of patients undergo-ing early PCI after thrombolysis in AMI (p<0.05). The ROC curve was established and the area under the curve (AUC) of GRACE score, DFR, and combined detection were 0.815, 0.783, and 0.894, respectively, and the sensitivity and spec-ificity were 80.24%, 60.42%, 83.71%, 66.78%, 91.42% and 77.83%, respectively. The AUC, sen-sitivity, and specificity of combined detection were higher than those of the two alone and had a higher predictive value for the short-term prognosis of patients.CONCLUSIONS: The GRACE score combined with DFR was of great value in diagnosing the short-term prognosis of patients undergoing PCI early after thrombolysis for AMI. Further-more, the GRACE score, DFR, ejection fraction, number of lesion branches, and Killip classifi-cation were all important factors influencing the short-term prognosis of patients, which were of great significance in determining the prognosis of patients.