机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Laboratory of Allergic Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
IntroductionOlfactory dysfunction (OD) is a typical symptom of chronic rhinosinusitis (CRS), which adversely affects the patient's quality of life and results in mood depression. Studies investigating the impairment of olfactory epithelium (OE) have indicated that inflammation-induced cell damage and dysfunction in OE plays a vital role in the development of OD. Consequently, glucocorticoids and biologics are beneficial in the management of OD in CRS patients. However, the mechanisms underlying OE impairment in CRS patients have not been fully elucidated.Areas coveredThis review focuses on mechanisms underlying inflammation-induced cell impairment in OE of CRS patients. Additionally, the methods used for detection of olfaction and both currently available and potentially new clinical treatments for OD are reviewed.Expert opinionChronic inflammation in OE impairs not only olfactory sensory neurons but also non-neuronal cells that are responsible for regeneration and support for neurons. The current treatment for OD in CRS is mainly aimed at attenuating and preventing inflammation. Strategies for use of combinations of these therapies may achieve greater efficacy in restoration of the damaged OE and consequently better management of OD.
基金：
national key Ramp;D program of China [2022YFC2504100]; national natural science foundation of China [82025010, 82171109]; program for the Changjiang scholars and innovative research team [IRT13082]; Beijing municipal administration of hospitals' Dengfeng/Youth plan [DFL20190202, QML20200202]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-022]
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Laboratory of Allergic Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No.1, DongJiaoMingXiang, DongCheng District, Beijing 100730, China[*2]Beijing TongRen Hospital, Capital Medical University, No. 1, DongJiaoMinXiang, DongCheng District, Beijing, China
推荐引用方式(GB/T 7714)：
Song Jing,Wang Ming,Wang Chengshuo,et al.Olfactory dysfunction in chronic rhinosinusitis: insights into the underlying mechanisms and treatments[J].EXPERT REVIEW OF CLINICAL IMMUNOLOGY.2023,19(8):993-1004.doi:10.1080/1744666X.2023.2235891.
APA：
Song, Jing,Wang, Ming,Wang, Chengshuo&Zhang, Luo.(2023).Olfactory dysfunction in chronic rhinosinusitis: insights into the underlying mechanisms and treatments.EXPERT REVIEW OF CLINICAL IMMUNOLOGY,19,(8)
MLA：
Song, Jing,et al."Olfactory dysfunction in chronic rhinosinusitis: insights into the underlying mechanisms and treatments".EXPERT REVIEW OF CLINICAL IMMUNOLOGY 19..8(2023):993-1004
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