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The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps

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收录情况： ◇ SCIE

作者：
Xu Zhaofeng[1,2] * ; Huang Yanran[1,2,8,9] * ; Meese Tim[4] ; Van Nevel Sharon[2] ; Holtappels Gabriele[2] ; Vanhee Stijn[2,6] ; Barbara M. Br¨oker[7] ; Li Zhengqi[1] ; de Meester Ellen[4] ; De Ruyck Natalie[2] ; Van Zele Thibaut[2] ; Gevaert Philip[2] ; Van Nieuwerburgh Filip[4] ; Zhang Luo[8,9] ; Shamji Mohamed H[5] ; Wen Weiping[1,7,*1] ; Zhang Nan[1,2,*2] ; Bachert Claus[1,2,3,11,*3] ;
机构： [1]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, Guangzhou, China [2]Upper Airway Research Laboratory, Ghent University, Ghent, Belgium [3]Clinic for ENT diseases and head and neck surgery, University Clinic Münster, Münster, Germany [4]NXTGNT, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium [5]National Heart and Lung Institute, Imperial College London, and NIHR Imperial Biomedical Research Centre, United Kingdom [6]VIB-UGent, Center for Inflammation Research, Gent 9052, Belgium [7]The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China [8]Department of Allergy, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China [9]Beijing key laboratory of nasal diseases, Beijing Institute of Otolaryngology, Beijing, PR China [10]Institute of Immunology, University Medicine Greifswald, Greifswald, Germany [11]Division of ENT diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden
出处：
DOI： 10.1016/j.clim.2023.109791
ISSN：

关键词： Chronic rhinosinusitis with nasal polyps scRNA-seq Immune profiles Tissue remodeling Type 2 immune responses

摘要：
Uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with elevated levels of type 2 inflammatory cytokines and raised immunoglobulin concentrations in nasal polyp tissue. By using single-cell RNA sequencing, transcriptomics, surface proteomics, and T cell and B cell receptor sequencing, we found the predominant cell types in nasal polyps were shifted from epithelial and mesenchymal cells to inflammatory cells compared to nasal mucosa from healthy controls. Broad expansions of CD4 T effector memory cells, CD4 tissue-resident memory T cells, CD8 T effector memory cells and all subtypes of B cells in nasal polyp tissues. The T and B cell receptor repertoires were skewed in NP. This study highlights the deviated immune response and remodeling mechanisms that contribute to the pathogenesis of uncontrolled severe CRSwNP. CLINICAL IMPLICATIONS: We identified differences in the cellular compositions, transcriptomes, proteomes, and deviations in the immune profiles of T cell and B cell receptors as well as alterations in the intercellular communications in uncontrolled severe CRSwNP patients versus healthy controls, which might help to define potential therapeutic targets in the future.Copyright © 2023. Published by Elsevier Inc.

基金：
ZX is a visiting scholar at the Upper Airways Research Laboratory (URL; head: Prof Dr. Claus Bachert) of Ghent University and is supported by Kelin's scholarship provided by the First Affiliated Hospital of Sun Yat-sen University. YH is a joint PhD student of URL Ghent University and Capital Medical University and is supported by a Chinese Scholarship Council fellowship(202008110300). This study was also supported by FWO Flanders (FWO-EOS Project G0G2318N), an unrestricted grant from Sanofi Belgium, and grants from National Natural Science Foundation of China (8201001110, 82301272, 82301282).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2021]版：
Q1 IMMUNOLOGY
最新[2024]版：
Q2 IMMUNOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, Guangzhou, China [2]Upper Airway Research Laboratory, Ghent University, Ghent, Belgium
共同第一作者：
通讯作者：
通讯机构： [1]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, Guangzhou, China [2]Upper Airway Research Laboratory, Ghent University, Ghent, Belgium [3]Clinic for ENT diseases and head and neck surgery, University Clinic Münster, Münster, Germany [7]The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China [11]Division of ENT diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden [*1]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, No.58 Zhong Shan Er Lu, 510080 Guangzhou, China [*2]Upper Airways Research Laboratory (URL), University Hospital Ghent, Corneel Heymanslaan 10, B-9000 Ghent, Belgium. [*3]Clinic for ENT diseases and head and neck surgery, University Clinic Münster, Kardinal-von Galen Ring 10, 48149 Münster, Germany.
推荐引用方式(GB/T 7714)：
Xu Zhaofeng,Huang Yanran,Meese Tim,et al.The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps[J].CLINICAL IMMUNOLOGY.2023,256:109791.doi:10.1016/j.clim.2023.109791.
APA：
Xu Zhaofeng,Huang Yanran,Meese Tim,Van Nevel Sharon,Holtappels Gabriele...&Bachert Claus.(2023).The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps.CLINICAL IMMUNOLOGY,256,
MLA：
Xu Zhaofeng,et al."The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps".CLINICAL IMMUNOLOGY 256.(2023):109791

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