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Neuroimaging Correlates with Clinical Severity in Wilson Disease: A Multiparametric Quantitative Brain MRI

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机构： [1]From the Department of Neurology,The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. [2]Department of Neurology ,Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Shanghai Key Laboratory of Magnetic Resonance,School of Physics and Electronic Science, East China Normal University, Shanghai, China. [4]Department of Neurology,Weifang People's Hospital, Weifang, China. [5]Department of Neurology ,Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. [6]Department of Neurology ,Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [7]Shanghai Key Laboratory of Magnetic Resonance ,School of Physics and Electronic Science, East China Normal University, Shanghai, China

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Previous studies have reported metal accumulation and microstructure changes in deep gray nuclei (DGN) in Wilson disease (WD). However, there are limited studies that investigate whether there is metal accumulation and microstructure changes in DGN of patients with WD with normal-appearing routine MRI. This study aimed to evaluate multiparametric changes in DGN of WD and whether the findings correlate with clinical severity in patients with WD.The study enrolled 28 patients with WD (19 with neurologic symptoms) and 25 controls. Fractional anisotropy (FA), mean diffusivity (MD), and magnetic susceptibility in globus pallidus, pontine tegmentum, dentate nucleus, red nucleus, head of caudate nucleus, putamen, substantia nigra, and thalamus were extracted. Correlations between imaging data and the Unified Wilson's Disease Rating Scale (UWDRS) neurologic subitems were explored.FA, MD, and susceptibility values were higher in multiple DGN of patients with WD than controls (P < .05). Patients with WD without abnormal signals in DGN on routine MRI also had higher FA, MD, and susceptibility values than controls (P < .017). We found that UWDRS neurologic subscores correlated with FA and susceptibility values of DGN (P < .05). In addition, we also found that FA and susceptibility values in specific structures correlated with specific neurologic symptoms of WD (ie, tremor, parkinsonism, dysarthria, dystonia, and ataxia) (P < .05).Patients with WD have increased FA, MD, and susceptibility values even before the lesion is morphologically apparent on routine MRI. The increased FA and susceptibility values correlate with clinical severity of WD.© 2024 by American Journal of Neuroradiology.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经成像 3 区核医学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区核医学 3 区临床神经病学 3 区神经成像

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出版当年[2022]版：

Q2 CLINICAL NEUROLOGY Q2 NEUROIMAGING Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2024]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROIMAGING Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 3.7 最新[2024版] 3.7 最新五年平均 3.5 出版当年[2022版] 4.1 出版当年五年平均 4.966 出版前一年[2021版] 3.1 出版后一年[2023版]

第一作者：

第一作者机构： [1]From the Department of Neurology,The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. [2]Department of Neurology ,Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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通讯作者：

通讯机构： [7]Shanghai Key Laboratory of Magnetic Resonance ,School of Physics and Electronic Science, East China Normal University, Shanghai, China [*1]Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, 3663 North Zhongshan Rd, Shanghai 200062, China

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