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Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes

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机构： [1]Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China [2]NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai 200031, China [3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai 200031, China [4]Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai 200031, China [5]Division of Arts and Sciences, NYU Shanghai, Shanghai, China [6]Center for Neural Science and Department of Psychology, New York University, New York, USA [7]NYU-ECNU Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai 200031, China

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关键词： Keratoconus Quantitative contrast sensitivity Visual acuity

摘要：

To compare the characteristics of the quantitative contrast sensitivity function (qCSF) in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and investigate the associated factors.A cross-sectional study.This study included 43 eyes of 43 patients with Early-KC (including subclinical keratoconus [SKC] and forme fruste keratoconus [FFKC]) and 77 NC eyes of 77 participants with corrected distance visual acuity (CDVA) all ≥ 20/20. Contrast sensitivity (CS) was assessed using the qCSF tests. Subgroup analysis was performed according to keratoconus type(SKC and FFKC) and astigmatism(cylindrical refraction >-1.0D or ≤-1.0D).Sex ratio, spherical refraction, and spherical equivalent (SE) varied significantly between the two groups (all P < 0.01). The area under log CSF (AULCSF), CSF Acuity, and CS at low (1.0 and 1.5 cycles per degree [cpd]) and high (12.0 and 18.0 cpd) spatial frequencies decreased significantly in the Early-KC group than that in the NC group (all P < 0.05). The subgroup analysis revealed a similar decrease in the SKC group (all P < 0.05). AULCSF, CSF Acuity, and CS at high spatial frequencies of patients with cylindrical refraction ≤-1.0D in the Early-KC group decreased significantly (all P < 0.05) than those in the NC group. The index of vertical asymmetry and index of height decentration correlated negatively with CS at 1.5 cpd (r= -0.321 and -0.306; both P < 0.05).CS decreased significantly at low and high spatial frequencies in Early-KC, though with normal CDVA. The qCSF test can sensitively reflect visual performance in early keratoconus.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 4 区医学

小类 | 3 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区眼科学

第一作者：

第一作者机构： [1]Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China [2]NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai 200031, China [3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai 200031, China [4]Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai 200031, China

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通讯作者：

通讯机构： [1]Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China [2]NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai 200031, China [3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai 200031, China [4]Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai 200031, China

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Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes

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