详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

A super soft thermoplastic biodegradable elastomer with high elasticity for arterial regeneration

3| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China [2]Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China [3]Department of Cardiology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China [4]Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [5]Department of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

出处：

DOI：

ISSN：

关键词： Thermoplastic elastomer Biodegradable elastomer High elasticity Cell infiltration Artery-matched elasticity Arterial regeneration

摘要：

Elastomers with innovative performance will provide new opportunities for solving problems in soft tissue repair, such as arterial regeneration. Herein, we present a thermoplastic biodegradable elastomer (PPS) that differs from the rigid, low-elastic traditional ones. It shows super softness (0.41 ± 0.052 MPa), high stretchability (3239 ± 357 %), and viscoelasticity similar to natural soft tissues. In addition, it also has good processability and appropriate degradability, estimated at 4-8 months for complete degradation in vivo. This excellent overall performance makes it a great support material for soft tissue repair and a powerful modifying agent for improving existing materials. For example, introducing it into poly(l-lactide) scaffolds through thermally induced phase separation can create a unique microporous structure with interconnected large pores (diameter >10 μm), demonstrating high efficiency in inducing cell infiltration. Blending it with poly(ε-caprolactone) through electrospinning can produce a composite fibrous film with significantly improved comprehensive performance, displaying artery-matched mechanical properties. Building on the above, we constructed a tri-layer tissue-engineered vascular graft for arterial regeneration, exhibiting promising remodeling outcomes in rabbits.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

JCR分区：

出版当年[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

最新[2024]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 12.9 最新[2024版] 13.4 最新五年平均 12.8 出版当年[2023版] 13.1 出版当年五年平均 14 出版前一年[2022版] 12.9 出版后一年[2024版]

第一作者：

第一作者机构： [1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China [2]Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China

通讯作者：

通讯机构： [3]Department of Cardiology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China [4]Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Histopathological Characteristics and Inflammatory Cell Infiltration in Sinonasal Inverted Papilloma [2]The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer [3]Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice [4]FK506 prolongs corneal allograft survival and prevents dendritic cell infiltration in an MDSC-dependent manner [5]Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report [6]Identification of hub genes and immune cell infiltration characteristics in chronic rhinosinusitis with nasal polyps: Bioinformatics analysis and experimental validation [7]树突状细胞密度、p53表达在进展期胃癌中的临床意义 [8]树突状细胞浸润、微血管密度在进展期胃癌中的预后意义 [9]高表达白细胞介素10的b细胞群抑制牙周炎症组织中cd4阳性t细胞浸润的研究 [10]cibersort分析胰腺导管腺癌神经侵袭对免疫浸润的影响