Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension
This study investigated the association between serum small peptides and arteriosclerosis (AS) in hypertensive patients. Sixty hypertensive patients (with and without AS) and 30 healthy individuals were enrolled. Untargeted metabolomics identified 120 peptides in AS patients, 136 in hypertensive patients, and 59 shared peptides. LASSO regression identified key peptides differentiating hypertensive patients with AS from those without. Peptides like Thr-Ile, Phe-Asp-Lys, and Lys-Ile-Val-Lys were upregulated in AS, while others like Gln-Glu and Lys-Lys were higher in non-AS patients. The diagnostic model showed AUCs of 0.896 for AS and 0.909 for non-AS. Elevated levels of Lys-Ile-Val-Lys and Phe-Asp-Lys were linked to increased carotid intima-media thickness, indicating higher AS risk.Graphical AbstractThis study successfully identified the specific small peptides in hypertensive patients with AS using untargeted metabolomics. These peptides were significantly upregulated in the hypertension with AS group, highlighting their potential as early biomarkers.
基金：
This study was supported by National Natural Science Foundation
of China (NO.82170450).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区医学：研究与实验
JCR分区：
出版当年[2023]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Shanghai Jiao Tong Univ, TONG REN Hosp, Dept Cardiol, Dept Urol,Sch Med, Shanghai 200336, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Fang Yunfeng,Yue Jingwen,Zhang Min,et al.Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension[J].JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH.2025,18(3):660-669.doi:10.1007/s12265-025-10616-z.
APA：
Fang, Yunfeng,Yue, Jingwen,Zhang, Min&Jiang, Li.(2025).Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension.JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH,18,(3)
MLA：
Fang, Yunfeng,et al."Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension".JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 18..3(2025):660-669
