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Effects of orientation of myocardial fibers on the contractility of left ventricle

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机构: [1]Chinese Acad Sci, LNM, Inst Mech, Beijing 100190, Peoples R China [2]Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China [3]Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing 100083, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Cardiovasc Ctr, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China [5]Beijing Inst Technol, Sch Aerosp Engn, Dept Mech, Beijing, Peoples R China
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关键词: Myocardial fibers Orientation angle Contractility Left ventricle Non-linear finite element method

摘要:
Myocardial fibers of the left ventricle (LV) play a pivotal role in electrical conduction, mechanical contraction, and numerous clinical malfunctions. While the general fiber orientation of the LV has been revealed through histological analysis and magnetic resonance diffusion tensor imaging, its impact on LV deformation remains largely unknown. In this paper, we adopt an idealized hollow semi-ellipsoid LV model, allowing for adjustable fiber orientations using a widely-accepted rule-based method. Simulations are conducted using a robustly coupled excitation-contraction nonlinear finite element algorithm. Our primary focus is on exploring the orientation angle of regularly-distributed fibers and the proportion of chaotic fibers, whose orientation angles are randomly assigned, on the end-systolic volume and ejection fraction of the LV. By employing this model, we successfully recreate the changes in LV volume over a cardiac cycle and capture the typical twisting motion observed in clinical practice. Furthermore, our findings reveal that when myocardial fibers are regularly distributed and the orientation angle increases, the ejection fraction of the LV decreases along with an increase in end-systolic volume, indicating a decline in LV contractility. Additionally, both the proportion and spatial distribution of chaotic fibers within the LV influence its contractility. Specifically, an LV with a higher proportion of chaotic fibers in the basal area exhibits weaker contractility. These results provide deeper insights into the quantitative influence of myocardial fibers on LV contractility and failure, offering valuable information for further research and clinical applications.

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出版当年[2025]版:
大类 | 3 区 医学
小类 | 3 区 工程:生物医学 3 区 材料科学:生物材料
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 工程:生物医学 3 区 材料科学:生物材料
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出版当年[2023]版:
Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS
最新[2024]版:
Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

影响因子: 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

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第一作者机构: [1]Chinese Acad Sci, LNM, Inst Mech, Beijing 100190, Peoples R China [2]Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
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通讯机构: [1]Chinese Acad Sci, LNM, Inst Mech, Beijing 100190, Peoples R China [2]Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
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