机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China[3]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[4]National Clinical Research Center for Eye Diseases, Shanghai, China[5]Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China[6]Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
PurposeThis study examines the protective effects of fenofibrate on retinal health in diabetic retinopathy, focusing on its ability to reduce inflammation, oxidative stress, and restore autophagy while preventing ferroptosis.MethodsUsing a streptozotocin (STZ)-induced diabetic rat model and cultured ARPE-19 cells under high glucose conditions, we assessed the impact of fenofibrate on oxidative stress markers, autophagy-related proteins, and tight junction integrity. Fenofibrate's role in modulating inflammation and preventing ferroptosis was also evaluated.ResultsFenofibrate treatment reduced ROS production and NADPH oxidase activity, alleviating oxidative stress in retinal tissues. Additionally, fenofibrate enhanced autophagy, as indicated by increased LC3 expression, and maintained tight junction protein expression. These effects contributed to the stabilization of cellular homeostasis, potentially slowing disease progression.ConclusionFenofibrate offers significant protective effects in diabetic retinopathy by reducing inflammation and oxidative stress, promoting autophagy, and inhibiting ferroptosis, making it a promising therapeutic option for managing the disease.
基金：
Shanghai Key Laboratory of Ocular Fundus Diseases [20180801]
第一作者机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China[3]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[4]National Clinical Research Center for Eye Diseases, Shanghai, China[5]Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China[6]Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
