机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Physiology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China
The macula, a cone photoreceptor-dense region critical for highacuity vision, undergoes pathological degeneration in Stargardt
disease type 1 (STGD1), an autosomal recessive juvenile disorder
characterized by genetic heterogeneity and variable clinical manifestations. Pathogenesis is predominantly attributed to mutations
in ABCA4, which disrupt retinal pigment epithelium (RPE) homeostasis through toxic lipofuscin accumulation, inducing apoptosis
and subsequent photoreceptor loss [1–3].
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Ya,Lin Qiang,He Hai-Long,et al.Juvenile macular degeneration in nonhuman primates generated by germline knockout of ABCA4 gene[J].Science Bulletin.2025,70(14):2237-2240.doi:10.1016/j.scib.2025.04.077.
APA：
Ma Ya,Lin Qiang,He Hai-Long,Liu Yi-Xin,Li Min...&Jin Zi-Bing.(2025).Juvenile macular degeneration in nonhuman primates generated by germline knockout of ABCA4 gene.Science Bulletin,70,(14)
MLA：
Ma Ya,et al."Juvenile macular degeneration in nonhuman primates generated by germline knockout of ABCA4 gene".Science Bulletin 70..14(2025):2237-2240
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