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Clinical characteristics of atrophic macular hole in pathologic myopia: A multicenter study

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机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China. [2]Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Institute of Fundus Diseases, Zhengzhou University, Zhengzhou, Henan, China. [3]Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. [4]Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. [5]Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Henan Key Laboratory of Ophthalmology and Visual Science, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No. 7 Weiwu Road, Zhengzhou, 450000, Henan, China.

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关键词： Pathologic myopia Myopic macular degeneration Myopic macular atrophy Macular hole

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This study aims to describe and analyze the clinical characteristics of atrophic macular hole (AMH), a severe complication in patients with pathologic myopia (PM).A multicenter, retrospective analysis was conducted involving 17 patients (17 eyes) diagnosed with AMH and 52 patients (52 eyes) diagnosed with simple macular hole (SMH) in PM from January 2023 to December 2023. Clinical data and multimodal images were collected. The age, gender, spherical equivalent (SE), axial length (AL), and best-corrected visual acuity (BCVA) of patients with AMH were described and their imaging characteristics analyzed.Of the 17 patients diagnosed with AMH, 15 (88.24 %) were female; the mean age was 64.59±12.61 years; the SE was -17.85±4.15 D; the AL was 30.40±1.67 mm; and the BCVA was 1.30 (1.00, 1.35) logMAR. Eleven eyes (64.71 %) exhibited myopic foveoschisis, seven eyes showed choroidal neovascularization (Fuchs spot), one eye had a concomitant epiretinal membrane, and no cases of retinal detachment involving the macula were observed. Axial length and neovascularization were significant correlates of BCVA in AMH patients (P < 0.05). Compared with SMH in PM, patients with AMH were older (t = 2.247, P = 0.028) and had worse BCVA (Z = 375, P = 0.037); no significant differences were found between the two groups in terms of gender, SE, and AL (P > 0.05).We propose the term "atrophic macular hole" to describe a condition resembling a macular hole accompanied by atrophy of the RPE and choroid, caused by progressive degeneration of the outer retina or traction of the eyeball, which severely impairs central vision in patients.Copyright © 2025. Published by Elsevier B.V.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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出版当年[2023]版：

Q2 ONCOLOGY

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Q3 ONCOLOGY

影响因子： 2.6 最新[2024版] 3.1 最新五年平均 3.1 出版当年[2023版] 3.3 出版当年五年平均 3.3 出版前一年[2022版] 2.6 出版后一年[2024版]

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第一作者机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.

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