机构：[1]Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA.[2]Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.[3]MerexAgRight Farm, Ltd., Kitale, Kenya.[4]Division of Statistical Genomics, Washington University, St. Louis, MO, USA.[5]Department of Epidemiology, University of Regensburg, Regensburg, 93051, Germany.[6]Department of Social Medicine, Population and Public Health, University of California, Riverside School of Medicine, Riverside, CA, 92521, USA.[7]Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DK-2200, Denmark.[8]The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.[9]Institut Pasteur, Universite Paris Cite, Department of Computational Biology, F-75015, Paris, France.[10]Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA.[11]Department of Biostatistics, University of Washington, Seattle, WA, 98101, USA.[12]Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.[13]Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore.[14]Department of Engineering Technology, University of Houston, Sugar Land, TX, 77479, USA.[15]Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.[16]Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.[17]Department of Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil.[18]Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, SP, 05403-900, Brazil.[19]Department of Biostatistics, Boston University, Boston, MA, 02118, USA.[20]Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, 27701-2047, USA.[21]Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.[22]Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.[23]Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.[24]Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.[25]McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.[26]Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.[27]Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.[28]Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA.[29]Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.[30]Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.[31]IQVIA, 1101 CT, Amsterdam, the Netherlands.[32]Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.[33]Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.[34]Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.[35]Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland.[36]Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Vaud, 1008, Switzerland.[37]Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.[38]Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.[39]Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany.[40]German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, 17475, Germany.[41]Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.[42]Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.[43]McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.[44]Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29169, USA.[45]Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX, 77030, USA.[46]Houston Methodist Debakey Heart and Vascular Center, Houston, TX, 77030, USA.[47]Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA.[48]Institute for Minority Health Research, University of Illinois Chicago, Chicago, IL, 60612, USA.[49]Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, 63110, USA.[50]Division of Cardiology, Washington University, St. Louis, MO, 63110, USA.[51]Department of Epidemiology, University of Washington, Seattle, WA, USA.[52]Department of Medicine, University of Washington, Seattle, WA, USA.[53]Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.[54]College of Pharmacy, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada.[55]Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA.[56]Department of Psychology, San Diego State University, San Diego, CA, USA.[57]Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70100, Finland.[58]Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.[59]Institute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland.[60]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[61]Department of Psychology and Logopedics, University of Helsinki, Helsinki, 00014, Finland.[62]University of Mississippi Medical Center, Jackson, MS, 39213, USA.[63]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.[64]Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.[65]Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, 27701-2047, USA.[66]Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.[67]Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.[68]Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.[69]Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, CH- 1011, Lausanne, Switzerland.[70]Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, the Netherlands.[71]Veritas Management Group, Inc., Alpharetta, GA, 30072, USA.[72]Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.[73]Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.[74]Department of Health Services Research, School of Medicine and Health Services, Carl von Ossietzky Universitat Oldenburg, Oldenburg, 26111, Germany.[75]Institute for Health Economics and Health Care Management, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.[76]Division of Preventive Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205, USA.[77]Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, 98195, USA.[78]Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, 119228, Singapore.[79]Department of Pediatrics, LA Biomed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.[80]Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.[81]Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.[82]Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.[83]Nuffield Department of Population Health, University of Oxford, Oxford, UK.[84]Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.[85]Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.[86]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[87]Department of Human Genetics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.[88]Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.[89]School of Public Health, Jackson State University, Jackson, MS, 39213, USA.[90]Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.[91]Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.[92]German Center for Diabetes Research (DZD), Partner Munchen-Neuherberg, Neuherberg, Germany.[93]German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 17475, Germany.[94]Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, 17489, Germany.[95]Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.[96]Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, the Netherlands.[97]Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA.[98]Icelandic Heart Association, Icelandic Heart Association, Kopavogur, 201, Iceland.[99]Faculty of Medicine, University of Iceland, Reykjavik, Iceland.[100]Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil.[101]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.[102]Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.[103]Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, USA.[104]Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.[105]Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA.
This project was largely supported by two grants from the U.S. National Heart, Lung,
and Blood Institute (NHLBI), the National Institutes of Health, R01HL118305 and
R01HL156991. This research was supported in part by the Intramural Research
Program of the National Human Genome Research Institute (NHGRI) in the Center for
Research on Genomics and Global Health (CRGGH—Z01HG200362). CRGGH is also
supported by the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), the Center for Information Technology, and the Office of the
Director at the National Institutes of Health. Tuomas O. Kilpeläinen was supported
by grants from the Novo Nordisk Foundation (NNF18CC0034900, NNF21SA0072102,NNF22OC0074128, NNF23SA0084103). W. Jim Gauderman was supported by the
National Cancer Institute (NCI; P01 CA196569).
医学