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A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy

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收录情况： ◇ SCIE

作者：
Xu Jianxiang[1] * ; Wang Yingying[2] * ; Williams Gareth R[3] ; Zheng Yilu[1] ; Zhang Yanyan[1] ; Wang Tong[1] ; Du Chengrong[2] ; Wang Yu[4,5] ; Wu Ying-Li[2] ; Zhu Li-Min[1] ;
机构： [1]College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China. [2]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [3]UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. [4]International Union Laboratory on Acupuncture Based Target Discovery, International Joint Laboratory on Acupuncture Neuro-immunology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China [5]Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出处：
DOI： 10.1016/j.jcis.2025.138100
ISSN：

关键词： Metal-dependent programmed cell death Cuproptosis Ferroptosis Cancer metalloimmunotherapy Catalytic cascade Multimodal imaging

摘要：
Excessive intracellular accumulation of metal ions results in metal-dependent programmed cell death, including ferroptosis and cuproptosis. However, cancer cells have defences against these processes, which allow them to resist therapy. Therefore, this work reports a laser-controlled cascade bioreactor based on gold and silica-coated Cu- and Mn-doped iron oxide nanocrystals (IONCs) loaded with the drug disulfiram (DSF). The resultant DSF/IONC@Au/MSN-TA nanoparticles (NPs) can deliver synergistic tumor metalloimmunotherapy through ferroptosis and cuproptosis. Under near-infrared laser (NIR) irradiation, DSF is released and chelates with Cu2+ to form Cu+ species in cancer cells, which leads to mitochondrial dysfunction via cuproptosis. The presence of gold nanodots on the DSF/IONC@Au/MSN-TA NPs allows them to consume intracellular glucose and sensitize cancer cells to cuproptosis. The DSF/IONC@Au/MSN-TA NPs induce ferroptosis via waterfall-like cyclic catalytic reactions, and iron ions released by the NPs consume glutathione (GSH), thereby enhancing sensitivity to cuproptosis and ferroptosis. The presence of manganese ions augments the efficacy of these processes and additionally allows imaging to be performed. A detailed physicochemical characterization of the NPs is reported, along with a series of assays to study the mechanisms of their biocatalytic activity. The NPs' biocompatibility is also established, and they are found to be appropriate for bioimaging and theranostic applications. Our work thus offers an innovative route for targeted tumor metalloimmunotherapy.Copyright © 2025 Elsevier Inc. All rights reserved.

基金：
This work was supported by the Science and Technology Commission of Shanghai Municipality [grant numbers 22520710400, 21WZ2501300, 20DZ2254900].
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外文
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出版当年[2025]版：
大类 | 1 区 化学
小类 | 2 区 物理化学
最新[2025]版：
大类 | 1 区 化学
小类 | 2 区 物理化学
JCR分区：
出版当年[2023]版：
Q1 CHEMISTRY, PHYSICAL
最新[2024]版：
Q1 CHEMISTRY, PHYSICAL

影响因子： 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

第一作者：
第一作者机构： [1]College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China.
共同第一作者：
通讯作者：
通讯机构： [4]International Union Laboratory on Acupuncture Based Target Discovery, International Joint Laboratory on Acupuncture Neuro-immunology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China [5]Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
推荐引用方式(GB/T 7714)：
Xu Jianxiang,Wang Yingying,Williams Gareth R,et al.A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy[J].Journal Of Colloid And Interface Science.2025,699:138100.doi:10.1016/j.jcis.2025.138100.
APA：
Xu Jianxiang,Wang Yingying,Williams Gareth R,Zheng Yilu,Zhang Yanyan...&Zhu Li-Min.(2025).A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.Journal Of Colloid And Interface Science,699,
MLA：
Xu Jianxiang,et al."A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy".Journal Of Colloid And Interface Science 699.(2025):138100

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