机构:[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Key Laboratory of Otolaryngology Head and Neck, Beijing, China.首都医科大学附属同仁医院[3]Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.医技科室病理科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Tuberculous otitis media (TOM) is a rare form of chronic otitis media, which presents diagnostic challenges due to nonspecific symptoms.To characterize the clinical features and identify strategies for early diagnosis.A retrospective analysis was conducted on 32 patients (40 ears) diagnosed with TOM between 2002 and 2024. Clinical, audiologic, radiologic, and laboratory findings were reviewed.Mean diagnostic delay was 28.9 months. Persistent otorrhea (90%) and hearing loss (HL) (100%) were predominant. Tympanic membrane findings varied: single perforation (70%), multiple (12.5%), and intact (17.5%). Granulations were universal. Age stratification revealed conductive HL and pneumatized mastoids predominated in patients <40 years, while mixed HL and mixed-type mastoid were more common in patients >40 years (p = 0.016, p = 0.005). Bone destruction was evident in 25% of the cases. Mastoid type correlated with HL patterns in non-destructive cases (p = 0.040). Interferon-gamma release assay (IGRA) and polymerase chain reaction (PCR) showed relatively high detection rates.Early suspicion of TOM in refractory/recurrent otitis media, combined with IGRA/PCR screening, prompt imaging, and consideration of age-specific patterns, facilitates timely diagnosis. Surgical biopsy remains critical for confirmation. Integration of age-stratified clinical, laboratory, and radiological findings improves detection accuracy and patient outcomes.
第一作者机构:[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.[2]Key Laboratory of Otolaryngology Head and Neck, Beijing, China.
通讯作者:
通讯机构:[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.[2]Key Laboratory of Otolaryngology Head and Neck, Beijing, China.
推荐引用方式(GB/T 7714):
Zhang Na,Wang Danni,Zou Qijuan,et al.Clinical characteristics of tuberculous otitis media: when to sound the alarm?[J].Acta Oto-Laryngologica.2025,1-9.doi:10.1080/00016489.2025.2522899.
APA:
Zhang Na,Wang Danni,Zou Qijuan,Ma Xiaobo,Li Yi...&Zhao Shouqin.(2025).Clinical characteristics of tuberculous otitis media: when to sound the alarm?.Acta Oto-Laryngologica,,
MLA:
Zhang Na,et al."Clinical characteristics of tuberculous otitis media: when to sound the alarm?".Acta Oto-Laryngologica .(2025):1-9