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Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study

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资源类型：
Pubmed体系：
作者：
Dun Changchang[1,2] * ; Li Yutong[1,2] ; Lei Wenbin[3] ; Li Yun[4] ; Yang Hui[5] ; Yasen Yalikun[6] ; Alimu Nilipaer[6] ; Lei Dapeng[7] ; Chen Dongyan[7] ; Hua Qingquan[8] ; Xu Zhen[8] ; Zhang Zhe[9] ; Wang Guangke[10] ; Wang Weiwei[10] ; Shi Li[11] ; Wang Xin[12] ; Zhao Xuelian[2] ; Hu Shangying[2] ; Ni Xiaoguang[2] ; Zhang Jie[13] ; Wang Jun[14] ; Zhao Fanghui[1,2] ;
机构： [1]School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China [2]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. [3]Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. [4]Department of Otorhinolaryngology, Head and Neck Surgery, Hunan Children's Hospital, Changsha 410007, China. [5]Department of Otolaryngology-Head & Neck Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. [6]Department of Otorhinolaryngology, The First Hospital of Xinjiang Medical University, Urumchi 830011, China. [7]Department of Otorhinolaryngology, Qilu Hospital of Shandong University, National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan 250012, China. [8]Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. [9]Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. [10]Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China. [11]Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. [12]Department of otorhinolaryngology, The First Hospital of Jilin University, Changchun 130021, China. [13]Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. [14]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China.
出处：
DOI： 10.1016/j.ijid.2025.107972
ISSN：

关键词： Juvenile-onset recurrent respiratory papillomatosis Human papillomavirus Disease characteristics Economic burden Health inequality

摘要：
To assess the demographic and clinical characteristics, treatment and health outcome, and economic burden of JoRRP in China.We identified twelve hospitals mainly responsible for JoRRP management across China to enroll patients presenting for JoRRP between Jan 1, 2011, and Dec 31, 2021. Data were primarily extracted from medical records, and missing values were additionally collected through telephone or outpatient interviews by two researchers independently. We used counts (proportions) and median values (interquartile range, IQR) to describe data. We applied the Lorenz curve and the concentration index (C-index) to indicate the wealth-related and education-related inequalities in JoRRP.Of the 361 enrolled JoRRP patients, the median age at first diagnosis was 2.7 years (IQR: 1.5-5.0). During the 7.2-year median follow-up, we observed that 314 (87.0%) patients experienced relapse and 125 (38.0%) patients underwent aggressive clinical course. The median value for the estimated total economic costs per patient was 8717.5$ (IQR: 4700.6$-15359.1$) and the occurrence of catastrophic health expenditure was concentrated in families with low incomes and less-educated parents.Chinese JoRRP patients experienced significant disease burden characterized by severe clinical symptoms and substantial economic costs. Strategic healthcare plans for JoRRP are needed for disease mitigation in China.Copyright © 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved.

基金：
The work was supported by the Investigator-Initiated Studies Program of Merck Sharp & Dohme LLC (grant number MISP- 100929 ) and Chinese Academy of Medical Sciences Initiative for Innovative Medicine (grant number 2021-I2M-1-004 ).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 传染病学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 传染病学
第一作者：
第一作者机构： [1]School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China [2]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
通讯作者：
通讯机构： [1]School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China [2]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
推荐引用方式(GB/T 7714)：
Dun Changchang,Li Yutong,Lei Wenbin,et al.Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study[J].International Journal Of Infectious Diseases : IJID : Official Publication Of The International Society For Infectious Diseases.2025,107972.doi:10.1016/j.ijid.2025.107972.
APA：
Dun Changchang,Li Yutong,Lei Wenbin,Li Yun,Yang Hui...&Zhao Fanghui.(2025).Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study.International Journal Of Infectious Diseases : IJID : Official Publication Of The International Society For Infectious Diseases,,
MLA：
Dun Changchang,et al."Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study".International Journal Of Infectious Diseases : IJID : Official Publication Of The International Society For Infectious Diseases .(2025):107972

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