机构：[1]Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.[2]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Beijing, China.[3]Tsinghua Medicine, Tsinghua University, Beijing, China.[4]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.[5]Rothschild Foundation Hospital, Paris, France.[6]Department of Ophthalmology, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore.[7]Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, United States.[8]Duke-NUS Graduate Medical School, Singapore, Singapore.[9]Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.[10]Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, Georgia, United States.[11]Emory Empathetic AI for Health Institute, Emory University, Atlanta, Georgia, United States.
To investigate optic nerve head (ONH) deformations caused by horizontal eye movements in high myopia (HM) using in vivo optical coherence tomography (OCT) imaging and finite-element (FE) modeling, and to identify factors influencing these deformations.A total of 28 HM eyes and 28 non-HM eyes were imaged at baseline, 20° adduction, and 20° abduction positions using OCT. Lamina cribrosa (LC) effective strains were quantified using a three-dimensional tracking algorithm. A baseline FE model of an emmetropic eye with an axial length of 23.5 mm and normal tissues structures and a HM model with elongated axial length and thinner sclera were developed. The effects of varying scleral stiffness and the eye movement center on gaze-induced ONH deformations were explored.In vivo measurement showed that LC strains were significantly greater in HM eyes than in non-HM eyes during adduction (5.95% ± 3.52% vs. 3.65% ± 1.85%; P = 0.002) and abduction (3.35% ± 1.94% vs. 2.29% ± 1.65%; P = 0.016). Strains correlated positively with axial length. FE modeling demonstrated greater gaze-induced LC strains in the HM model compared to the emmetropic model, in both adduction and abduction. A softer sclera reduced LC strains in the HM model, whereas a forward shift in the eye movement center (relative to the geometric center, as seen in HM eyes) increased strain.This study demonstrates that gaze-induced ONH deformations increase with axial elongation. The findings highlight the role of scleral stiffness and eye movement center position in modulating ONH biomechanics, contributing to the understanding of glaucomatous, glaucoma-like, and non-glaucomatous optic neuropathy in HM.
基金：
the National Natural Science Foundation of China (12472304, 12272030); grants from the Beijing Natural Science Foundation (Z240017, L248028); Fundamental Research Funds for the Central Universities; Emory Eye Center
(Emory University School of Medicine start-up funds to MJAG);
a Challenge Grant from Research to Prevent Blindness to the
Department of Ophthalmology at Emory University; and a grant
from the National Institutes of Health (P30EY06360 to Atlanta
Vision Community).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Tingting,Wang Ya Xing,Jonas Jost B,et al.Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length[J].Investigative Ophthalmology & Visual Science.2025,66(9):21.doi:10.1167/iovs.66.9.21.
APA：
Liu Tingting,Wang Ya Xing,Jonas Jost B,Hoang Quan V,Girard Michaël J A&Wang Xiaofei.(2025).Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length.Investigative Ophthalmology & Visual Science,66,(9)
MLA：
Liu Tingting,et al."Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length".Investigative Ophthalmology & Visual Science 66..9(2025):21
