机构：[1]The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[2]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.[3]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[4]Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[5]MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.[6]Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.[7]Atlanta VA Health Care System, Decatur, GA, USA.[8]Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.[9]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.[10]Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.[11]Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.[12]Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.[13]Department of Public Health, Section of Epidemiology, Algorithmic Fairness Research Group, University of Copenhagen, Copenhagen, Denmark.[14]Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[15]Center for Genomic Data Analytics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[16]Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.[17]Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[18]Department of Population Health Sciences, Geisinger, Danville, PA, USA.[19]Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[20]Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.[21]William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.[22]Digital Environment Research Institute, Queen Mary University of London, London, UK.[23]Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.[24]Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.[25]Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.[26]Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.[27]Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[28]Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.[29]Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.[30]Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.[31]Nuffield Department of Population Health, University of Oxford, Oxford, UK.[32]Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK.[33]Center for Health Data Science, Section for Health Data Science and Artificial Intelligence, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[34]Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.[35]Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.[36]Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.[37]Division of Biostatistics and Epidemiology, RTI International, Durham, NC, USA.[38]Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.[39]Swiss Institute of Bioinformatics, Lausanne, Switzerland.[40]Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.[41]Department of Family Medicine, University of California, San Diego, La Jolla, CA, USA.[42]Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.[43]Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.[44]Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[45]Harvard Medical School, Boston, MA, USA.[46]Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.[47]Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.[48]Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.[49]Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.[50]Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.[51]Quantinuum Research, LLC, Wayne, PA, USA.[52]Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.[53]Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.[54]Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany.[55]Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.[56]NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.[57]Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.[58]Department of Congenital Disorders and Danish National Biobank, Statens Serum Institut, Copenhagen, Denmark.[59]Department of Public Health, University of Copenhagen, Copenhagen, Denmark.[60]Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.[61]Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.[62]Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.[63]Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.[64]Usher Institute, University of Edinburgh, Edinburgh Bioquarter, Edinburgh, UK.[65]Centre for Public Health, Queen's University of Belfast, Northern Ireland, UK.[66]Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.[67]Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.[68]Center for Spatial and Functional Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.[69]Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.[70]Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.[71]Department of Kinesiology, Faculty of Medicine, Universite Laval, Quebec, QC, Canada.[72]Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.[73]23andMe, Inc., Sunnyvale, CA, USA.[74]Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.[75]Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.[76]Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.[77]Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Universita degli Studi di Sassari, Sassari, Italy.[78]Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.[79]Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.[80]Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.[81]Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.[82]Department of Nutrition Science and Dietetics, School of Health Sciences, University of the Peloponnese, Kalamata, Greece.[83]Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.[84]Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.[85]Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.[86]Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[87]Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.[88]German Center for Diabetes Research (DZD), Neuherberg, Germany.[89]COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.[90]Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.[91]Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.[92]Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.[93]Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.[94]Department of Computational Genomics, National Institute of Genomic Medicine, Mexico City, Mexico.[95]Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.[96]Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.[97]Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.[98]Rogel Cancer Center, University of Michigan Medicine, Ann Arbor, MI, USA.[99]Eurac Research Institute for Biomedicine, Bolzano, Italy.[100]Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.[101]Jackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS, USA.[102]Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.[103]Cardiovascular Medicine/Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.[104]Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.[105]Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.[106]The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.[107]BiRC - Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.[108]The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.[109]Department of Medical Sciences, Uppsala University, Uppsala, Sweden.[110]Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.[111]Translational Research Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.[112]Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.[113]Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.[114]Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.[115]Bristol Dental School, University of Bristol, Bristol, UK.[116]Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.[117]Framingham Heart Study, Framingham, MA, USA.[118]Department of Clinical Sciences in Malmo, Lund University, Lund, Sweden.[119]Veterans Affairs Boston Healthcare System, Boston, MA, USA.[120]Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.[121]Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.[122]School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.[123]Leipzig University, Medical Faculty, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.[124]Leipzig University, Medical Faculty, LIFE Research Center for Civilization Diseases, Leipzig, Germany.[125]Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.[126]Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.[127]School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.深圳市康宁医院深圳医学信息中心[128]Institute for Global Health and Development, Peking University, Beijing, China.[129]Program in Metabolism and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.[130]Center for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.[131]Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.[132]Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongwon-gun, Republic of Korea.[133]Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.[134]Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.[135]Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.[136]Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.[137]Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.[138]Department of Biobank Research, Umea University, Umea, Sweden.[139]Department of Odontology, Umea University, Umea, Sweden.[140]Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.[141]Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[142]Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.[143]Faculty of Medicine, University of Kelaniya, Colombo, Sri Lanka.[144]Osaka University Graduate School of Medicine, Osaka, Japan.[145]Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.[146]Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.[147]Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.[148]Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.[149]Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, Scotland.[150]Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea.[151]Center for Clinical Epidemiology, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.[152]SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.[153]Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden.[154]Department of Computer Science, University of Toronto, Toronto, ON, Canada.[155]Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada.[156]Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Qld University of Technology, Kelvin Grove, Queensland, Australia.[157]Oneomics, Soonchunhyang Mirai Medical Center, Gyeonggi-do, Republic of Korea.[158]Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.[159]Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.[160]Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.[161]Data Tecnica International, Glen Echo, MD, USA.[162]Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[163]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[164]Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Rockville, MD, USA.[165]Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.[166]Department of Mathematics and Statistics, St. Cloud State University, St. Cloud, MN, USA.[167]Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.[168]Montreal Heart Institute, Montreal, QC, Canada.[169]Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.[170]MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.[171]Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.[172]Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.[173]Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.[174]Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.[175]Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.[176]Department of Genetics & Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.[177]National and Kapodistrian University of Athens, Dromokaiteio Psychiatric Hospital, Athens, Greece.[178]NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.[179]Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.[180]MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.[181]Department of Community Health & Epidemiology and Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.[182]Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.[183]Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander Universitat Erlangen-Nurnberg, Erlangen, Germany.[184]Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience Amsterdam UMC/Vrije Universiteit, Amsterdam, The Netherlands.[185]Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, USA.[186]Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.[187]Department of Clinical Chemistry, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.[188]Institute for Cardiogenetics, University of Lubeck, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel and University Heart Center Lubeck, Lubeck, Germany.[189]Institute of Epidemiology and Biobank PopGen, University Hospital Schleswig Holstein, Campus Kiel and Kiel University, Kiel, Germany.[190]Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.[191]Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.[192]Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.[193]Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.[194]Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.[195]Korea Institute of Science and Technology, Gangneung Institute of Natural Products, Gangneung, Republic of Korea.[196]Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark.[197]Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.[198]Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.[199]Health Campus The Hague/Public Health and Primary Care, Leiden University Medical Center, The Hague, The Netherlands.[200]Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.[201]Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.[202]The National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark.[203]Medical School, University of Split, soltanska 2, Split, Croatia.[204]Algebra University College, Zagreb, Croatia.[205]Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.[206]Center for Non-Communicable Diseases, Karachi, Pakistan.[207]Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.[208]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[209]Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.[210]Department of Medicine, Division of Endocrinology, Diabetes & Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.[211]Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.[212]Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.[213]Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden.[214]Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.[215]Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.[216]Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.[217]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.[218]Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.[219]Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.[220]Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.[221]Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.[222]Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.[223]Icelandic Heart Association, Kopavogur, Iceland.[224]deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.[225]Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.[226]VA Palo Alto Health Care System, Palo Alto, CA, USA.[227]Gladstone Institute of Data Science and Biotechnology, Gladstone Institute, San Francisco, CA, USA.[228]Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.[229]DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.[230]Cardiology Division, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.[231]Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.[232]Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.[233]Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.[234]Central Diagnostic Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.[235]Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.[236]Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.[237]Laboratory of Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences Institute, Amsterdam, The Netherlands.[238]Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.[239]Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.[240]Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.[241]Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.[242]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[243]Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.[244]Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.[245]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[246]Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.[247]NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.[248]Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.临床科室眼科眼科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[249]Information Management Services, Inc., Calverton, UK.[250]Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.[251]Department of Dermatology, Medical University of Vienna, Vienna, Austria.[252]Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.[253]Department of Neurology, Oslo University Hospital, Oslo, Norway.[254]Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.[255]Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.[256]Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.[257]Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.[258]Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.[259]Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.[260]Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.[261]Department of Psychology, University of Minnesota, Minneapolis, MN, USA.[262]Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar.[263]Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt.[264]Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.[265]Department of Epidemiology and Biostatistics, Imperial College London, London, UK.[266]Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.[267]Victor Phillip Dahdaleh Heart & Lung Research Institute, Cambridge Biomedical Campus, Cambridge, UK.[268]Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.[269]Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.[270]Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.[271]Amsterdam Cardiovascular Sciences Institute, Amsterdam, The Netherlands.[272]Molecular Epidemiology Section, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.[273]Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[274]Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[275]Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.[276]Latin American Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.[277]Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.[278]Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico.[279]Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.[280]Department of Cardiology, Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.[281]Institute of Health Informatics, University College London, London, UK.[282]The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.[283]HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.[284]HUNT Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.[285]Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.[286]Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.[287]Geriatric Unit, Azienda Toscana Centro, Florence, Italy.[288]Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia.[289]Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University (JNU), New Delhi, India.[290]Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.[291]Human Genetics Center and Department of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.[292]Department of Nephrology and Rheumatology, Kliniken Sudostbayern, Regensburg, Germany.[293]KfH Kidney Center Traunstein, Traunstein, Germany.[294]USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.[295]Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines.[296]Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.[297]Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.[298]Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.[299]Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.[300]Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UK.[301]Imperial College Healthcare NHS Trust, Imperial College London, London, UK.[302]Lightening Lives, Hyderabad, India.[303]Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore.[304]Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.[305]Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.[306]Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.[307]Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.[308]IRCCS Neuromed, Pozzilli (IS), Pozzilli, Italy.[309]Department of Neurology, Division of Vascular Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.[310]Department of Neurology, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.[311]Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.[312]Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy.[313]Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.[314]Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.[315]Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.[316]Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, The Netherlands.[317]Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.[318]Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.[319]Department of Oncology, University of Cambridge, Cambridge, UK.[320]Department of Nephrology and Medical Intensive Care, Charite - Universitatsmedizin Berlin, Berlin, Germany.[321]Department of General Practice, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.[322]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.[323]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.[324]Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.[325]Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.[326]Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.[327]Department of Cardiology, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.[328]Faculty of Medicine, UNSW Sydney, Kensington, New South Wales, Australia.[329]Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.[330]Department of Medicine, Harvard Medical School, Boston, MA, USA.[331]Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.[332]Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.[333]Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.[334]Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Helsingborg, Sweden.[335]Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.[336]Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.[337]Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Mü[375]nchen Research Center for Environmental Health, Neuherberg, Germany.[338]College of Allied Health Professions, University of Nebraksa Medical Center, Omaha, NE, USA.[339]Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud Publica and Centro de Estudios en Diabetes, Cuernavaca Morelos, Mexico.[340]Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.[341]Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.[342]Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.[343]Faculty of Medicine, University of Iceland, Reykjavik, Iceland.[344]Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.[345]Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.[346]Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.[347]Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.[348]Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.[349]Research Unit of Biomedicine and Internal Medicine, Biocenter of Oulu, Medical Research Center, University of Oulu, Oulu, Finland.[350]Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.[351]Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.[352]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia.[353]Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia.[354]Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.[355]Department of Genetics, Shanghai-MOST Key Laboratory of Heath and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China.[356]Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.[357]Department of Pediatrics, Tampere University Hospital, Tampere, Finland.[358]Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.[359]Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.[360]South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.[361]Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.[362]Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.[363]Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulun, Finland.[364]Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.[365]Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.[366]The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.[367]Institut Francais de Myopie, Hopital Fondation Rothschild, Paris, France.[368]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.[369]Privatpraxis Prof. Jonas und Dr. Panda-Jonas, Heidelberg, Germany.[370]L V Prasad Eye Institute, Hyderabad, India.[371]Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands.[372]Netherlands Heart Institute, Utrecht, The Netherlands.[373]Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.[374]Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.[375]Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.[376]Department of Ophthalmology, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Republic of Korea.[377]Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.[378]NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.[379]German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.[380]Verve Therapeutics, Boston, MA, USA.[381]Brigham and Women's Hospital, Boston, MA, USA.[382]Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.[383]Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.[384]Saevit Eye Hospital, Goyang-si, Republic of Korea.[385]Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.[386]Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.[387]Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.[388]German Center for Cardiovascular Research, Partner Site, Hamburg/Kiel/Lubeck, Germany.[389]Atrial Fibrillation NETwork, Munster, Germany.[390]UCL Brain Sciences, University College London, London, UK.[391]Clinicum, University of Helsinki, Helsinki, Finland.[392]Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[393]Department of Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.[394]Minerva Foundation Institute for Medical Research, Helsinki, Finland.[395]First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.[396]MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.[397]National Heart and Lung Institute, Imperial College London, London, UK.[398]Medical Department III - Endocrinology, Nephrology, Rheumatology, Leipzig University Medical Center, Leipzig, Germany.[399]Institute for Social and Economic Research, University of Essex, Wivenhoe Park, UK.[400]Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.[401]Department of Medicine, University of Colorado at Denver, Aurora, CO, USA.[402]Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Berlin, Germany.[403]Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.[404]Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea.[405]Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China.[406]Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China.[407]Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.[408]Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China.浙江省肿瘤医院[409]Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[410]Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.[411]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.[412]Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA.[413]Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.[414]University of Lausanne, Lausanne, Switzerland.[415]SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.[416]Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.[417]Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.[418]Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.[419]Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.[420]Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.[421]Centre for Vision Research and Department of Ophthalmology, Westmead Millennium Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.[422]Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.[423]Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.[424]Data Tecnica, Washington, DC, USA.[425]Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.[426]Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[427]Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.[428]Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.[429]Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology Tampere University, Tampere, Finland.[430]Institute of Human Genetics, School of Medicine & University Hospital Bonn, Bonn, Germany.[431]Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.[432]Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden.[433]Laboratorio de Inmunogenomica y Enfermedades Metabolicas, Instituto Nacional de Medicina Genomica, CDMX, Mexico City, Mexico.[434]Paavo Nurmi Centre and Unit for Health and Physical Activity, University of Turku, Turku, Finland.[435]Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.[436]Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.[437]Centre Nutrition, sante et societe (NUTRISS), Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, Canada.[438]Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[439]Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig Maximilians Universitat Munchen, Munich, Germany.[440]Population, Policy and Practice, UCL Great Ormond Street Hospital Institute of Child Health, London, UK.[441]Department of Epidemiology, University of Washington, Seattle, WA, USA.[442]Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.[443]Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.[444]Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.[445]InFLAMES Research Flagship, University of Turku, Turku, Finland.[446]Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital Attikon, Athens, Greece.[447]Center for Biostatistics and Data Science, Washington University School of Medicine, St. Louis, MO, USA.[448]Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, USA.[449]Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Dongdaemun-gu, Seoul, Republic of Korea.[450]Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.[451]Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.[452]Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.[453]Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.[454]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.[455]Department of Medicine, University of Ibadan, Ibadan, Nigeria.[456]Department of Cardiology and Department of Medicine, Columbia University, Columbia, NY, USA.[457]Department of Pediatrics, Section of Genetics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.[458]Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.[459]Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.[460]Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.[461]Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.[462]Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.[463]Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.[464]Deutsches Herzzentrum Munchen, Cardiology, Deutsches Zentrum fur Herz- und Kreislaufforschung (DZHK) - Munich Heart Alliance and Technische Universitat Munchen, Munchen, Germany.[465]School of Biomedical Science and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.[466]Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.[467]Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.[468]Department of Social Medicine, Population and Public Health, School of Medicine, University of California, Riverside, Riverside, CA, USA.[469]Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.[470]Department of Cardiology, Clinical Sciences, Lund University and Skane University Hospital, Lund, Sweden.[471]The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.[472]Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.[473]Population Health Research Institute, St. George's University of London, London, UK.[474]Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.[475]Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.[476]Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.[477]Helsinki University Hospital, Helsinki, Finland.[478]Helsinki University Central Hospital, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.[479]Folkhalsan Research Center, Helsinki, Finland.[480]Department of Public Health, University of Helsinki, Helsinki, Finland.[481]Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.[482]Unidad de Biologia Molecular y Medicina Genomica, Instituto de Investigaciones Biomedicas, UNAM, Mexico City, Mexico.[483]Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.[484]Department of Geriatric Medicine, Amsterdam Public Health, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.[485]Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.[486]School of Nutrition, Faculty of Agricultural and Food Sciences, Universite Laval, Quebec, QC, Canada.[487]Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.[488]Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.[489]Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.[490]Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.[491]Hero DMC Heart Institute, Dayanand Medical College, Ludhiana, India.[492]Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.[493]Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.[494]USC Diabetes and Obesity Research Institute, Keck School of Medicine of USC, Los Angeles, CA, USA.[495]Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.[496]School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.[497]Diabetes Unit, KEM Hospital and Research Centre, Pune, India.[498]School of Life Sciences, Westlake University, Hangzhou, China.[499]Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.[500]Kurume University School of Medicine, Kurume, Japan.[501]Cancer Epidemiology and Prevention Program, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.[502]Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.[503]Technical University of Munich and Klinikum Rechts der Isar, TUM School of Medicine and Health, Munich, Germany.[504]Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.[505]Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.[506]Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.[507]Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.[508]Department of Medicine, Veterans Affairs Boston Healthcare System, Boston, MA, USA.[509]Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.[510]Department of Genetic Medicine and Development, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland.[511]McDonnell Genome Institute and Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.[512]Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.[513]Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.[514]Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka, Japan.[515]Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.[516]MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda.[517]Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.[518]Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA.[519]The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@sund.ku.dk.[520]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ruth.loos@sund.ku.dk.[521]Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[522]The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
第一作者机构：[1]The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[2]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.[3]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[4]Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
通讯作者：
通讯机构：[519]The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@sund.ku.dk.[520]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ruth.loos@sund.ku.dk.[521]Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[522]The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
推荐引用方式(GB/T 7714)：
Smit Roelof A J,Wade Kaitlin H,Hui Qin,et al.Polygenic prediction of body mass index and obesity through the life course and across ancestries[J].Nature Medicine.2025,doi:10.1038/s41591-025-03827-z.
APA：
Smit Roelof A J,Wade Kaitlin H,Hui Qin,Arias Joshua D,Yin Xianyong...&Loos Ruth J F.(2025).Polygenic prediction of body mass index and obesity through the life course and across ancestries.Nature Medicine,,
MLA：
Smit Roelof A J,et al."Polygenic prediction of body mass index and obesity through the life course and across ancestries".Nature Medicine .(2025)
医学