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Retinal Vascular Fingerprints as Novel Biomarkers for Primary Angle Closure Disease Progression

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机构： [1]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and, Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Institute of Ophthalmology, Beijing, China. [3]Ningxia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China. [4]Qingdao University, Qingdao, China. [5]Centre for Eye and Vision Research (CEVR), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China. [6]Linfen Yaodu Eye Hospital, Linfen, Shanxi, China.

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关键词： Primary angle closure disease Retinal vascular fingerprints Glaucomatous optic neuropathy

摘要：

To evaluate retinal vascular parameters across primary angle-closure disease (PACD) stages and explore their association with glaucomatous optic neuropathy (GON).A cross-sectional, hospital-based study.We enrolled 638 eyes from 425 participants aged ≥40 years with PACD and further classified them into primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG) groups.Retinal vascular parameters were measured using the Retinal-based Microvascular Health Assessment System and compared between 3 groups. A multivariable logistic mixed effects model was used to identify factors associated with the presence of GON.Vessel caliber, tortuosity, complexity, and branching angle parameters.No significant differences in retinal vascular parameters were found between PACS and PAC groups. Eyes in PACG showed significant vascular changes compared to PACS (P < 0.05). Elevated intraocular pressure (odds ratio [OR] = 2.44, P < 0.001), reduced arteriolar curve tortuosity (OR = 0.12, P = 0.002), arteriolar fractal dimension (OR = 0.08, P = 0.027), arteriolar branching angle (OR = 0.16, P = 0.004), and asymmetry ratio (OR = 0.10, P < 0.001 for artery and OR = 0.25, P = 0.023 for vein) were significantly associated with the presence of GON.Retinal "vascular geometric fingerprints" show significant alterations in eyes with PACG compared to PACS and are independently associated with the presence of GON. These findings offer new insights into the vascular changes in GON, and longitudinal studies are needed to determine their prognostic value and clinical utility in managing PACD.The author(s) have no proprietary or commercial interest in any materials discussed in this article.© 2025 by the American Academy of Ophthalmologyé.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

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出版当年[2023]版：

Q1 OPHTHALMOLOGY

最新[2024]版：

Q1 OPHTHALMOLOGY

影响因子： 4.6 最新[2024版] 4.6 最新五年平均 3.2 出版当年[2023版] 3.2 出版当年五年平均 0 出版前一年[2022版] 4.6 出版后一年[2024版]

第一作者：

第一作者机构： [1]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and, Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Institute of Ophthalmology, Beijing, China.

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通讯作者：

通讯机构： [1]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and, Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Institute of Ophthalmology, Beijing, China.

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