Background Liver dysfunction, which serves as a critical indicator of advanced liver disease and a driver of mortality in PLWH, is frequently accompanied by perturbations in serum potassium homeostasis. This study aims to investigate the association between serum potassium and liver dysfunction in PLWH, with identifying potential indicative value for risk stratification of hepatic outcomes. Methods A total of 2,725 PLWHs, with 10,718 measurements of serum potassium, were enrolled in this study. Piecewise linear mixed-effect model with smoothing function and Cox regression analysis were used to identify the association of serum potassium with liver dysfunction. Results A U-shaped relationship was identified between serum potassium and liver dysfunction, with a threshold of 4.25 mmol/L. Participants with baseline potassium > 4.25 mmol/L had a 27% (95% CI: 1.04-1.54) higher risk of mild liver dysfunction and a 48% (95% CI: 1.01-2.14) higher risk of severe liver dysfunction, which were confirmed by Kaplan-Meier analyses. Conclusions The study establishes serum potassium concentration as an independent predictor of liver dysfunction in PLWHs, highlighting the importance of potassium monitoring and management for this population.
基金：
This work was supported by Science and Technology Development Plan Project of Hangzhou (20201203B191); the Hepatology (Traditional Chinese and Western Medicine) of Hangzhou Medical Peak Subject, and 123 Talent Plan of Xixi hospital (2021).
第一作者机构：[1]Zhejiang Chinese Med Univ, Affiliated Hangzhou Xixi Hosp, Dept Hepatol, Hangzhou, Zhejiang, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China[3]Zhejiang Chinese Med Univ, Xixi Hosp Biobank, Affiliated Hangzhou Xixi Hosp, 2 Hengbu Rd, Hangzhou 310023, Zhejiang, Peoples R China[4]Zhejiang Chinese Med Univ, Affiliated Hangzhou Xixi Hosp, Dept Hepatol, 2 Hengbu Rd, Hangzhou 310023, Zhejiang, Peoples R China[8]Shanghai Jiao Tong Univ, Affiliated Tongren Hosp, Sch Med, Dept Lab Med, Shanghai, Peoples R China[9]Zhejiang Univ Technol, Coll Biol Engn, 6 Dist, Hangzhou 310014, Zhejiang, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Hong,Li Jiamin,Ma Wenjun,et al.Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV[J].AIDS RESEARCH AND THERAPY.2025,22(1):doi:10.1186/s12981-025-00766-0.
APA：
Liu, Hong,Li, Jiamin,Ma, Wenjun,Zhang, Xia,Bao, Jianfeng...&Liu, Fang.(2025).Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV.AIDS RESEARCH AND THERAPY,22,(1)
MLA：
Liu, Hong,et al."Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV".AIDS RESEARCH AND THERAPY 22..1(2025)
