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Effects of choline metabolite-trimethylamine N-oxide on immunometabolism in inflammatory bowel disease

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收录情况： ◇ SCIE

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机构： [1]Kunshan Hosp Chinese Med, Dept Prevent Treatment Dis, Kunshan, Peoples R China [2]Suzhou Key Lab Integrated Tradit Chinese & Western, Kunshan, Peoples R China [3]Kunshan Hosp Chinese Med, Dept Clin Nutr, Kunshan, Peoples R China [4]Southeast Univ, Zhongda Hosp, Sch Med, Nanjing, Peoples R China [5]Kunshan Hosp Chinese Med, Dept Gastroenterol, Kunshan, Peoples R China [6]Kunshan Hosp Chinese Med, Dept Proctol, Kunshan, Peoples R China [7]Southeast Univ, Nanjing Tongren Hosp, Hlth Management Ctr, Sch Med, Nanjing, Peoples R China

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关键词： trimethylamine N-oxide inflammatory bowel disease gut microbiota metabolites immunometabolism

摘要：

Trimethylamine N-oxide (TMAO), a key metabolite derived from the gut microbial metabolism of choline, has recently been implicated as a significant contributor to the development of several chronic diseases, including diabetes, cardiovascular disease, and chronic kidney disease. Its detrimental effects have garnered widespread attention in the scientific community. Inflammatory bowel disease (IBD), marked by persistent and recurring gastrointestinal inflammation, is a significant global health issue. Emerging evidence highlights a critical role for TMAO in the pathogenesis of IBD. This review comprehensively summarizes current research on the association between TMAO and IBD, with a particular focus on the mechanisms by which TMAO regulates immunometabolism in diseases.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2023]版：

Q1 IMMUNOLOGY

最新[2024]版：

Q1 IMMUNOLOGY

影响因子： 5.9 最新[2024版] 6.8 最新五年平均 5.7 出版当年[2023版] 6.8 出版当年五年平均 7.3 出版前一年[2022版] 5.9 出版后一年[2024版]

第一作者：

第一作者机构： [1]Kunshan Hosp Chinese Med, Dept Prevent Treatment Dis, Kunshan, Peoples R China [2]Suzhou Key Lab Integrated Tradit Chinese & Western, Kunshan, Peoples R China

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通讯作者：

通讯机构： [2]Suzhou Key Lab Integrated Tradit Chinese & Western, Kunshan, Peoples R China [5]Kunshan Hosp Chinese Med, Dept Gastroenterol, Kunshan, Peoples R China

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